The Contribution of Maternal ADHD Symptomatology, Maternal DAT1, and Home Atmosphere to Child ADHD Symptomatology at 7 Years of Age
The Contribution of Maternal ADHD Symptomatology, Maternal DAT1, and Home Atmosphere to Child ADHD Symptomatology at 7 Years of Age
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DOI：
10.1007/s10802-016-0230-0
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发表时间：
2017-04-01
影响因子：
3.6
通讯作者：
Berger, Andrea
中科院分区：
文献类型：
--
作者：
Auerbach, Judith G.;Zilberman-Hayun, Yael;Berger, Andrea
注意力缺陷/多动障碍（ADHD）母亲的孩子患有ADHD的遗传和环境风险增加。母亲的多巴胺受体基因（DAT 1），母亲的ADHD症状（多动-冲动，注意力不集中），和家庭气氛的独特和互动的贡献，以预测ADHD症状（多动-冲动，注意力不集中）在7岁的男孩（N = 96）进行了检查，使用数据从一个纵向研究的ADHD的家族风险。在研究的前6个月，母亲和她们的配偶完成了一份关于母亲多动症症状的问卷。4年后收集家庭气氛问卷数据。在7年的评估中，母亲报告了孩子的ADHD症状。消极的家庭气氛与儿童多动冲动和注意力不集中症状显著相关。母亲注意力不集中的症状显着相关的儿童症状的尺寸。回归模型，与儿童基因型和母亲的教育控制，母亲的注意力不集中的症状，母亲的DAT 1 10/10基因型，和家庭气氛中的儿童注意力不集中的症状的预测显示的主要影响。只有家庭气氛能预测儿童多动-冲动症状。家庭气氛×母亲多动-冲动症状交互作用对儿童多动-冲动症状有显著的预测作用。具有较高水平症状的男孩来自具有较高水平消极气氛的家庭，其母亲具有较高水平的多动-冲动症状。也有一个趋势（p = 0.075），母亲DAT 1 x家庭气氛的相互作用。注意力不集中症状水平较高的男孩来自消极气氛水平较高的家庭，其母亲具有纯合子10/10基因型。母亲杂合子9/10基因型不能预测儿童症状。
Children of mothers with attention-deficit/hyperactivity disorder (ADHD) have an increased genetic and environmental risk for ADHD. The unique and interactive contributions of a maternal dopamine receptor gene (DAT1), maternal ADHD symptoms (hyperactive- impulsive, inattentive), and home atmosphere to the prediction of ADHD symptoms (hyperactive- impulsive, inattentive) in 7- year-old boys (N = 96) were examined using data from a longitudinal study of familial risk for ADHD. During the first 6 months of the study, mothers and their spouses completed a questionnaire about the mother's ADHD symptoms. Home atmosphere questionnaire data were collected 4 years later. At the 7-year assessment, mothers reported on their child's ADHD symptoms. Negative home atmosphere was significantly associated with child hyperactive-impulsive and inattentive symptoms. Maternal inattentive symptoms were significantly correlated with both child symptom dimensions. Regression models, with child genotype and maternal education controlled, showed main effects for maternal inattentive symptoms, maternal DAT1 10/10 genotype, and home atmosphere in the prediction of child inattentive symptoms. Only home atmosphere predicted child hyperactive-impulsive symptoms. There was a significant home atmosphere x maternal hyperactive-impulsive symptoms interaction in the prediction of child hyperactive-impulsive symptoms. Boys with higher levels of symptoms came from homes characterized by higher levels of negative atmosphere and had mothers with higher levels of hyperactive-impulsive symptoms. There was also a trend (p = 0.075) for a maternal DAT1 x home atmosphere interaction. Boys with higher levels of inattentive symptoms came from homes with higher levels of negative atmosphere and had mothers with the homozygous 10/10 genotype. The maternal heterozygous 9/10 genotype did not predict child symptoms.