Morphologic and immunohistochemical findings in antibody-mediated rejection of the cardiac allograft
Morphologic and immunohistochemical findings in antibody-mediated rejection of the cardiac allograft
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DOI：
10.1016/j.humimm.2012.07.011
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发表时间：
2012-12-01
期刊：
影响因子：
2.7
通讯作者：
Fishbein, Michael C.
中科院分区：
文献类型：
--
作者：
Fishbein, Gregory A.;Fishbein, Michael C.
实体器官的抗体介导的排斥反应（AMR）的实体的认识和接受一直发展缓慢。最大的接受度和最多的信息与心脏移植有关。AMR被认为是抗体/补体介导的移植物微血管损伤，可导致同种异体移植物功能障碍、同种异体移植物丢失、加速移植物血管病变和死亡率增加。形态学特征是微血管损伤，毛细血管中免疫球蛋白和补体沉积，血管内巨噬细胞积聚，在更严重的情况下，微血管出血和血栓形成，受影响器官炎症和水肿。对AMR的发病机制、诊断标准和方法以及治疗策略的理解仍在发展中，本文将对此进行综述。(C)2012年美国组织相容性和免疫遗传学学会。爱思唯尔公司出版All rights reserved.
The recognition and acceptance of the entity of antibody-mediated rejection (AMR) of solid organs has been slow to develop. Greatest acceptance and most information relates to cardiac transplantation. AMR is thought to represent antibody/complement mediated injury to the microvasculature of the graft that can result in allograft dysfunction, allograft loss, accelerated graft vasculopathy, and increased mortality. The morphologic hallmark is microvascular injury with immunoglobulin and complement deposition in capillaries, accumulation of intravascular macrophages, and in more severe cases, microvascular hemorrhage and thrombosis, with inflammation and edema of the affected organ. Understanding of the pathogenesis of AMR, criteria and methods for diagnosis, and treatment strategies are still in evolution, and will be addressed in this review. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.