MICROBIAL PRODUCTS .8. AZINOTHRICIN, A NOVEL HEXADEPSIPEPTIDE ANTIBIOTIC
MICROBIAL PRODUCTS .8. AZINOTHRICIN, A NOVEL HEXADEPSIPEPTIDE ANTIBIOTIC
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DOI：
10.7164/antibiotics.39.17
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发表时间：
1986-01-01
影响因子：
3.3
通讯作者：
BLOUNT, JF
中科院分区：
文献类型：
--
作者：
MAEHR, H;LIU, CM;BLOUNT, JF
Azinothricin was isolated from the culture filtrate of Streptomyces sp. X-14950 in crystalline form. It represents a new type of hexadepsipeptide antibiotic as it contains a 19-membered cyclodepsipeptide ring composed of six unusual amino acids and bearing a novel C21 side chain. Azinothricin was identified as [(3S,4S,7R(S*),10S,17R,20S,23R)[2S(2''R*,5''S*,6''S*)3S*]]-.alpha.-ethyl-6-(3-ethyl-1,5-dimethyl-4-oxo-1,5-heptadienyl)-N-(1,8,14,15,18,21,27-heptaaza-21-hydroxy-7-(1-hydroxyethyl)-2,6,9,16,19,22-hexaoxo-4-isopropyl-20-(methoxymethyl)-17,18-dimethyl-5-oxatricyclo[21.4.0.010,15]heptacosan-3-yl)tetrahydro-.alpha.,2-dihydroxy-5-methyl-2H-pyran-2-acetamide and is primarily active agaisnt Gram-positive microorganisms.
