The Effect of Laterality and Primary Tumor Site on Cancer-Specific Mortality in Breast Cancer: A SEER Population-Based Study
The Effect of Laterality and Primary Tumor Site on Cancer-Specific Mortality in Breast Cancer: A SEER Population-Based Study
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偏侧性和原发肿瘤部位对乳腺癌癌症特异性死亡率的影响：一项基于 SEER 人群的研究。
DOI：
10.1371/journal.pone.0094815
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发表时间：
2014-04-16
期刊：
影响因子：
3.7
通讯作者：
Di, Gen-Hong
中科院分区：
文献类型：
--
作者：
Bao, Jing;Yu, Ke-Da;Di, Gen-Hong
背景：左侧乳腺癌患者与右侧乳腺癌患者相比，由于放射治疗后心脏毒性，总体存活率降低。然而，偏侧性和原发肿瘤部位对乳腺癌特异性死亡率(BCSM)的影响尚不清楚。患者和方法：我们分析了1990-2009年间305,443名年龄在20岁到79岁之间的乳腺癌患者的数据。这些数据来自美国国家癌症研究所的基于人群的监测、流行病学和最终结果(SEER)项目。结果：在多因素分析中，BCSM受原发肿瘤部位的影响(P
Background: Reduced overall survival has been observed in patients with left-sided versus right-sided breast cancer due to cardiac toxicity after radiotherapy. However, the effect of laterality and primary tumor site on breast cancer-specific mortality (BCSM) remains unclear.Patients and Methods: We analyzed data from 305,443 women ages 20- to 79-years-old diagnosed with breast cancer between 1990 and 2009. The data were obtained from the population-based Surveillance, Epidemiology, and End Results (SEER) program of the U. S. National Cancer Institute. The survival outcomes with regard to laterality and primary tumor site were compared using univariate and multivariate (Cox proportional hazards regression model) methods.Results: In the multivariate analysis, BCSM was affected by the primary tumor site (P