EFFECTS OF 6-HYDROXYDOPAMINE LESIONS OF THE NUCLEUS ACCUMBENS SEPTI ON PERFORMANCE OF A 5-CHOICE SERIAL REACTION-TIME TASK IN RATS - IMPLICATIONS FOR THEORIES OF SELECTIVE ATTENTION AND AROUSAL
EFFECTS OF 6-HYDROXYDOPAMINE LESIONS OF THE NUCLEUS ACCUMBENS SEPTI ON PERFORMANCE OF A 5-CHOICE SERIAL REACTION-TIME TASK IN RATS - IMPLICATIONS FOR THEORIES OF SELECTIVE ATTENTION AND AROUSAL
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DOI：
10.1016/s0166-4328(89)80048-8
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发表时间：
1989-06-01
影响因子：
2.7
通讯作者：
ROBBINS, TW
中科院分区：
文献类型：
--
作者：
COLE, BJ;ROBBINS, TW
6项实验研究了6-羟多巴胺（6-OHDA）诱导的伏隔核（NAS）损伤对空间辨别能力的影响。所使用的行为范式类似于伦纳德的人类5选择系列反应时间任务。6-OHDA病变在NAS中产生87%的多巴胺（DA）消耗，在前尾状核中只有少量（25%）的DA消耗，新皮质去甲肾上腺素（NA）消耗75%。损伤短暂地减弱了对基线计划的反应速度和冲动性，但不影响判别准确性。此外，病变减弱了由全身服用d -安非他明和在视觉歧视开始之前出现的大声白噪音爆发引起的过早反应的增加。然而，在这两种情况下，病变不影响判别的准确性。当试验间隔不可预测时，病变也仅对该范式的表现有极微小的影响。这些结果与先前报道的相同行为范式下由前脑NA消耗引起的行为影响模式形成对比。因此，它们完成了对反应的准确性和活力的双重分离，支持了唤醒型过程划分的理论。
Six experiments examined the effects of 6-hydroxydopamine (6-OHDA) induced leisons of the nucleus accumbens septi (NAS) on performance of a spatial discrimination. The behavioral paradigm used was an analogue of Leonard''s 5-choice serial reaction time task for humans. The 6-OHDA lesion produced an 87% depletion of dopamine (DA) in the NAS, only a minor (25%) depletion of DA in the anterior caudate, and a 75% depletion of neocortical noradrenaline (NA). The lesion transiently attenuated both the speed and impulsivity of responding on the baseline schedule, but did not affect discriminative accuracy. In addition, the lesion attenuated the increase in premature responding caused by both systemic administration of D-amphetamine and bursts of loud white noise, presented just prior to the onset of the visual discriminanda. However, the lesion did not affect discriminative accuracy in these 2 conditions. The lesion also only had extremely minor effects on performance of this paradigm when the intertrial intervals were unpredictable. These results contrast with the previously reported pattern of behavioral effects resulting from forebrain NA depletion in the same behavioral paradigm. They therefore complete a double dissociation of effects on accuracy and vigor of responding, supporting theories of a division of arousal-type processes.