Immunoglobulins and Innate Antimicrobial Factors in Whole Saliva of Patients with Insulin-dependent Diabetes Mellitus
Immunoglobulins and Innate Antimicrobial Factors in Whole Saliva of Patients with Insulin-dependent Diabetes Mellitus
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胰岛素依赖型糖尿病患者全唾液中的免疫球蛋白和先天抗菌因子
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
P. Tuohimaa
中科院分区：
文献类型：
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作者：
J. Tenovuo;O. Lehtonen;J. Vkari;H. Larjava;P. Vilja;P. Tuohimaa
我们分析了 35 名成年糖尿病患者及其年龄和性别匹配的非糖尿病临床健康对照者石蜡刺激的全唾液样本的流速和成分。所有患者均患有胰岛素依赖型糖尿病 (IDDM)，平均 (± S.D.) 病程为 14.0 ± 9.1 年。唾液分析包括总蛋白、淀粉酶、免疫球蛋白（同种型 A、G 和 M）以及非抗体、先天抗菌因子（溶菌酶、乳铁蛋白、唾液过氧化物酶、髓过氧化物酶、硫氰酸盐和次硫氰酸盐）的定量。糖尿病患者的全部唾液样本中 IgA (p < 0.001) 和 IgG (p < 0.05) 的含量显着高于对照组。研究组之间在流速、蛋白质含量、淀粉酶活性或 IgM 方面没有观察到差异。除唾液过氧化物酶外，两个研究组的先天防御因子水平相似，糖尿病患者的唾液过氧化物酶水平高于对照组（p < 0.02）。我们的结果表明，糖尿病患者整个唾液的抗菌防御能力并未受损。
We analyzed the flow rate and composition of paraffin-stimulated whole saliva samples from 35 adult diabetic patients and their age- and sex-matched, non-diabetic, clinically healthy controls. All patients had insulin-dependent diabetes (IDDM) with a mean (± S.D.) duration of 14.0 ± 9.1 years. The saliva analysis included the quantitation of total protein, amylase, immunoglobulins (isotypes A, G, and M), and the non-antibody, innate antimicrobial factors (lysozyme, lactoferrin, salivary peroxidase, myeloperoxidase, thiocyanate, and hypothiocyanite). The whole saliva samples from diabetic patients had significantly higher amounts of IgA (p < 0.001) and IgG (p < 0.05) than did the controls. No differences between the study groups were observed in flow rate, protein content, amylase activity, or IgM. The levels of innate defense factors were similar in both study groups except for salivary peroxidase, which was higher (p < 0.02) among diabetics than among controls. Our results indicate that the antimicrobial defense capacity of whole saliva is not impaired in diabetic patients.
影响因子：
4.3
作者：
FRIEDMAN, SA;MANDEL, ID;HERRERA, MS
通讯作者：
HERRERA, MS