The epigenetics of tumour initiation: cancer stem cells and their chromatin
The epigenetics of tumour initiation: cancer stem cells and their chromatin
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DOI：
10.1016/j.gde.2016.01.003
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发表时间：
2016-02-01
影响因子：
4
通讯作者：
Aznar Benitah, Salvador
中科院分区：
文献类型：
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作者：
Avgustinova, Alexandra;Aznar Benitah, Salvador
癌症干细胞 (CSC) 已在多种肿瘤中被发现，并因其移植后启动肿瘤、自我更新和重建肿瘤异质性的潜力而被定义。表观基因组的修饰可以通过影响基因组完整性、DNA 修复和肿瘤细胞可塑性来促进肿瘤的发生。重要的是，深入了解肿瘤转化背后的表观基因组改变可能会为染色质靶向癌症治疗开辟新途径，因为这些表观遗传变化本质上比硬连线基因组改变更容易受到抑制和逆转。在这里，我们讨论染色质状态和表观基因组不稳定性如何影响 CSC 功能。
Cancer stem cells (CSCs) have been identified in various tumours and are defined by their potential to initiate tumours upon transplantation, self-renew and reconstitute tumour heterogeneity. Modifications of the epigenome can favour tumour initiation by affecting genome integrity, DNA repair and tumour cell plasticity. Importantly, an in-depth understanding of the epigenomic alterations underlying neoplastic transformation may open new avenues for chromatin-targeted cancer treatment, as these epigenetic changes could be inherently more amenable to inhibition and reversal than hardwired genomic alterations. Here we discuss how CSC function is affected by chromatin state and epigenomic instability.