Chromosomal instability A composite phenotype that influences sensitivity to chemotherapy
Chromosomal instability A composite phenotype that influences sensitivity to chemotherapy
复制标题
DOI：
10.4161/cc.8.20.9690
复制
发表时间：
2009-10-15
期刊：
影响因子：
4.3
通讯作者：
Swanton, Charles
中科院分区：
文献类型：
--
作者：
McClelland, Sarah E.;Burrell, Rebecca A.;Swanton, Charles
染色体不稳定性（CIN）被定义为整个染色体或部分染色体的持续获得或丢失，是大多数实体瘤基因组不稳定性的主要原因。在许多实体肿瘤中，CIN与紫杉烷的内在耐药、获得性多药耐药和预后不良有关，尽管最近有证据表明铂类药物（如卡铂）可能特异性靶向CIN肿瘤。
Chromosomal instability (CIN) is defined as continual gain or loss of whole chromosomes or fractions of chromosomes and is a major cause of the genomic instability that characterizes most solid tumors. CIN is associated with intrinsic resistance to taxanes, acquired multidrug resistance and poor prognosis in many solid tumors, although recent evidence has shown that platinum agents, such as carboplatin, may specifically target CIN cancers.