The axon-glia unit in white matter stroke: mechanisms of damage and recovery.
The axon-glia unit in white matter stroke: mechanisms of damage and recovery.
复制标题
白质冲程中的轴突 - 格里亚单元：损害和恢复的机制。
DOI：
10.1016/j.brainres.2015.02.019
复制
发表时间：
2015-10-14
期刊：
影响因子：
2.9
通讯作者：
Carmichael ST
中科院分区：
文献类型：
--
作者：
Rosenzweig S;Carmichael ST
Approximately one quarter of all strokes in humans occur in white matter, and the progressive nature of white matter lesions often results in severe physical and mental disability. Unlike cortical grey matter stroke, the pathology of white matter stroke revolves around disrupted connectivity and injured axons and glial cells, rather than neuronal cell bodies. Consequently, the mechanisms behind ischemic damage to white matter elements, the regenerative responses of glial cells and their signaling pathways, all differ significantly from those in grey matter. Development of effective therapies for white matter stroke would require an enhanced understanding of the complex cellular and molecular interactions within the white matter, leading to the identification of new therapeutic targets. This review will address the unique properties of the axon-glia unit during white matter stroke, describe the challenging process of promoting effective white matter repair, and discuss recently-identified signaling pathways which may hold potential targets for repair in this disease.
