Red Blood Cell Transfusions in Preterm Infants: Is There a Difference Between Restrictive and Liberal Criteria?
Red Blood Cell Transfusions in Preterm Infants: Is There a Difference Between Restrictive and Liberal Criteria?
复制标题
早产儿红细胞输注：限制性标准和自由性标准之间有区别吗？
作者：
R. Swamy;N. Embleton
母亲接受青霉素治疗后婴儿感染风险的增加“应该谨慎地解释，因为接受青霉素治疗的母亲人数很少，而且可能没有足够的力量来检测微小但可能显著的差异。”1我们不同意爱德华兹和达夫的含蓄建议，即根据他们的研究，氨苄西林是一种可以接受的免疫保护剂。在预防新生儿早发性B组链球菌感染方面，氨苄西林并不比青霉素有优势，这正是IPAS的目的。我们认为，我们的研究支持青霉素的国家使用建议。他们的研究确实表明青霉素IPA可能存在风险，特别是与早发性SBI有关。我们建议，那些照顾SBI婴儿的人不应该因为得知婴儿的母亲接受了青霉素作为IPA而放心。
increase in risk for infant infection after maternal penicillin treatment “should be interpreted cautiously, however, because the numbers of mothers who received penicillin was small, and there may be insufficient power to detect a small but possibly significant difference.”1 We disagree with Edwards and Duff’s implicit suggestion that, based on their study, ampicillin is an acceptable agent as an IPA. Ampicillin provides no advantage over penicillin for the prevention of early-onset group B Streptococcus infections in newborns, the purpose of IPAs. We believe that our study supports the national recommendations for the use of penicillin. Their study does suggest that there may be risks associated with penicillin IPAs, particularly with respect to early-onset SBI. We suggest that those caring for infants with an SBI should not be reassured by learning that the infant’s mother had received penicillin as an IPA.