Differential effects of amphetamine and dopamine uptake blockers (cocaine, nomifensine) on caudate and accumbens dialysate dopamine and 3-methoxytyramine.
Differential effects of amphetamine and dopamine uptake blockers (cocaine, nomifensine) on caudate and accumbens dialysate dopamine and 3-methoxytyramine.
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发表时间：
1992-09
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通讯作者：
R. Kuczenski;D. Segal
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作者：
R. Kuczenski;D. Segal
有证据表明，一些苯丙胺类兴奋剂可能比尾状多巴胺更大程度地增强伏隔核透析液多巴胺。为了检验我们的假设，即递质反应的差异可能部分源于两个区域中释放的多巴胺代谢为 3-甲氧基酪胺的程度，我们比较了安非他明与摄取阻滞剂诺米芬辛和可卡因对尾状核和伏核透析液中多巴胺、其酸性代谢物和 3-甲氧基酪胺浓度的影响。仅在服用阻滞剂后，伏核多巴胺的百分比增加显着大于尾状核。所有三种药物均促进透析液 3-甲氧基酪胺的剂量依赖性增加，虽然暂时延迟，但通常与多巴胺的增加平行。然而，服用摄取阻滞剂后，尾状核中透析液 3-甲氧基酪胺与多巴胺的比例高于伏核。此外，使用安非他明后两个区域的酸性代谢模式相同，但使用摄取阻滞剂后却有质的不同。这些结果表明，尾状核和伏核中释放的多巴胺代谢为 3-甲氧基酪胺的相对程度可能导致多巴胺对摄取阻滞剂反应的区域差异。
Evidence suggests that some amphetamine-like stimulants may enhance accumbens dialysate dopamine to the greater extent than caudate dopamine. To test our hypothesis that the difference in transmitter response may derive, in part, from the degree to which released dopamine in the two regions is metabolized to 3-methoxytyramine, we compared the effects of amphetamine with the uptake blockers, nomifensine and cocaine, on caudate and accumbens dialysate concentrations of dopamine, its acid metabolites and 3-methoxytyramine. The percentage increases in accumbens dopamine were significantly greater than in caudate only after the uptake blockers. All three drugs promoted dose-dependent increases in dialysate 3-methoxytyramine which, although temporally delayed, generally paralleled the increases in dopamine. However, after the administration of uptake blockers, the ratio of dialysate 3-methoxytyramine to dopamine was greater in caudate than in accumbens. In addition, the acid metabolite patterns were the same in the two regions after amphetamine, but were qualitatively different after the uptake blockers. These results indicate that the relative degree of metabolism of released dopamine to 3-methoxytyramine in caudate and accumbens may contribute to the regional differences in dopamine response to uptake blockers.