THE DROSOPHILA SEGMENT POLARITY GENE DISHEVELLED ENCODES A NOVEL PROTEIN REQUIRED FOR RESPONSE TO THE WINGLESS SIGNAL
THE DROSOPHILA SEGMENT POLARITY GENE DISHEVELLED ENCODES A NOVEL PROTEIN REQUIRED FOR RESPONSE TO THE WINGLESS SIGNAL
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DOI：
10.1101/gad.8.1.118
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发表时间：
1994-01-01
影响因子：
10.5
通讯作者：
PERRIMON, N
中科院分区：
文献类型：
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作者：
KLINGENSMITH, J;NUSSE, R;PERRIMON, N
果蝇Wnt-1同源基因wingless（wg）在多种情况下参与模式信息的信号传导。在胚胎表皮中，Wg蛋白被分泌并被邻近的细胞摄取，其中它是维持犰狳蛋白的盘根错节的转录和积累所必需的。dsh基因介导这些信号事件以及胚胎中肠组织层中wg依赖的诱导。在成年人的发育过程中，wg的功能也需要dsh。总的来说，缺乏dsh的细胞不能采用Wg指定的命运。dsh自主地作用于细胞，表明它参与靶细胞对Wg信号的响应。DSH在胚胎中均匀表达，并编码一种没有已知催化基序的新蛋白质，尽管它与几种连接相关蛋白质共享同源结构域。我们的研究结果表明，dsh编码的Wg信号的特定组件，并说明Wnt蛋白可能利用一种新的细胞外信号转导机制。
The Drosophila Wnt-1 homolog, wingless (wg), is involved in the signaling of patterning information in several contexts. In the embryonic epidermis, Wg protein is secreted and taken up by neighboring cells, in which it is required for maintenance of engrailed transcription and accumulation of Armadillo protein. The dishevelled (dsh) gene mediates these signaling events as well as wg-dependent induction across tissue layers in the embryonic midgut. dsh is also required for the developmental processes in which wg functions in adult development. Overall, cells lacking dsh are unable to adopt fates specified by Wg. dsh functions cell autonomously, indicating that it is involved in the response of target cells to the Wg signal. dsh is expressed uniformly in the embryo and encodes a novel protein with no known catalytic motifs, although it shares a domain of homology with several junction-associated proteins. Our results demonstrate that dsh encodes a specific component of Wg signaling and illustrate that Wnt proteins may utilize a novel mechanism of extracellular signal transduction.