Discrimination learning in Rorasg and Grid2ho mutant mice
Discrimination learning in Rorasg and Grid2ho mutant mice
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DOI：
10.1016/j.nlm.2008.05.004
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发表时间：
2008-09-01
影响因子：
2.7
通讯作者：
Strazielle, C.
中科院分区：
文献类型：
--
作者：
Lalonde, R.;Strazielle, C.
在充满水的t迷宫中，将具有轻度小脑颗粒细胞变性的Rora（sg）突变体与具有更严重颗粒细胞变性和Purkinle细胞萎缩的Grid2（ha）突变体进行左、右和暗光辨别学习任务的比较。在明暗辨别学习过程中，两种突变体的习得率均有所减慢，但左右辨别学习过程中没有。然而，突变体在两项任务的逆转训练中都受到损害。相比之下，两种突变体在被动回避学习方面都与对照组不同。这些结果表明，小脑损伤小鼠在某些工具性学习任务中受到影响，并具有持续学习的倾向。(C) 2008爱思唯尔公司版权所有。
Rora(sg) mutants with mild cerebellar granule cell degeneration were compared to Grid2(ha) mutants with more severe granule cell degeneration as well as Purkinle cell atrophy for left-right and dark-light discrimination learning tasks in a water-filled T-maze. The acquisition rate of both cerebellar mutants was slowed down during light-dark but not left-right discrimination learning. However, the mutants were impaired in reversal training in both tasks. In contrast, neither mutant differed from controls in passive avoidance learning. These results indicate that mice with cerebellar damage are affected in some instrumental learning tasks and have perseverative tendencies. (C) 2008 Elsevier Inc. All rights reserved.