MHC and KIR Polymorphisms in Rhesus Macaque SIV Infection.
MHC and KIR Polymorphisms in Rhesus Macaque SIV Infection.
复制标题
DOI：
10.3389/fimmu.2015.00540
复制
发表时间：
2015
影响因子：
7.3
通讯作者：
Ansari AA
中科院分区：
文献类型：
--
作者：
Walter L;Ansari AA
自然杀伤淋巴细胞本质上是抵御病毒和恶性细胞等病原体的第一道防线。这些细胞的活性是通过特异性和多样性的杀伤细胞免疫球蛋白样受体(KIR)与靶细胞上高度多态的同源MHC I类蛋白相互作用来调节的。KIR和MHC-I配体的遗传变异性已被证明与对许多疾病的抵抗力有关，包括感染免疫缺陷病毒。感染人类免疫缺陷病毒-1(HIV-1)后的病程和进展基本上受到刺激性KIR3DS1受体和人类白细胞抗原-Bw4结合的影响。了解这样的基因相互作用不仅有助于抗病，而且有助于易感，也同样重要。最近在恒河猴艾滋病模型中报道了这种组合的遗传因素。在这里，我们回顾了恒河猴MHC I类和KIR基因系统以及它们的多态在SIV感染模型中的作用。
Natural killer lymphocytes are essentially involved as the first line of defense against agents such as viruses and malignant cells. The activity of these cells is regulated via interaction of specific and diverse killer cell immunoglobulin-like receptors (KIR) with the highly polymorphic cognate MHC class I proteins on target cells. Genetic variability of both KIR and MHC-I ligands has been shown to be associated with resistance to many diseases, including infection with the immunodeficiency virus. Disease course and progression to AIDS after infection with human immunodeficiency virus-1 (HIV-1) is essentially influenced by the presence of the stimulatory KIR3DS1 receptor in combination with HLA-Bw4. Knowledge of such genetic interactions that contribute to not only disease resistance but also susceptibility are just as important. Such combined genetic factors were recently reported in the rhesus macaque AIDS model. Here, we review the rhesus macaque MHC class I and KIR gene systems and the role of their polymorphisms in the SIV infection model.