Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of Taiwan: Metabolic significance of nonalcoholic fatty liver disease in nonobese adults
Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of Taiwan: Metabolic significance of nonalcoholic fatty liver disease in nonobese adults
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DOI：
10.1097/00004836-200609000-00016
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发表时间：
2006-09-01
影响因子：
2.9
通讯作者：
Yueh, Sen-Kou
中科院分区：
文献类型：
--
作者：
Chen, Chien-Hua;Huang, Min-Ho;Yueh, Sen-Kou
背景资料：非酒精性脂肪性肝病（NAFLD）的患病率是很少报道在Taiwan.Goals：为了确定NAFLD的患病率和危险因素在成年人口的Taiwan.Study：横断面社区研究检查了3245名成年人在农村的台湾。NAFLD的诊断标准为无过量饮酒、无慢性病毒性肝炎、无已知的肝病病因、超声检查符合脂肪肝。一般人群中NAFLD的危险因素是男性[比值比（OR），1.44; 95%可信区间（CI），1.09-1.90]，丙氨酸氨基转移酶（ALT）升高，（OR，5.66; 95%CI，3.99-8.01），肥胖（OR，7.21; 95% CI，5.29-9.84），空腹血糖≥ 126 mg/dL（OR，2.08; 95% CI，1.41-3.05），总胆固醇>= 240 mg/dL甘油三酯≥ 150 mg/dL（OR，1.76; 95% CI，1.32-2.35）和高尿酸血症（OR，1.53; 95% CI，1.16-2.01）。年龄≥ 65岁与NAFLD呈负相关（OR，0.53; 95%CI，0.36-0.77）。非肥胖受试者中唯一的NAFLD危险因素是年龄在40岁至64岁之间（OR，2.35; 95% CI，1.34-4.11，P = 0.003），ALT升高（OR，15.45; 95%CI，8.21-29.09，P < 0.001）和甘油三酯150 mg/dL（OR，2.48; 95%CI，1.42-4.32，P = 0.001）。在NAFLD受试者中，在存在每种代谢危险因素（如肥胖、空腹血糖>= 126 mg/dL、总胆固醇>= 240 mg/dL、甘油三酯>= 150 mg/dL和高尿酸血症）的情况下，ALT升高的患病率与ALT水平正常的受试者没有差异。NAFLD与ALT升高、肥胖、糖尿病、高胆固醇血症、高甘油三酯血症和高尿酸血症密切相关。在代谢紊乱中，
Background: The prevalence of nonalcoholic fatty liver disease (NAFLD) is rarely reported in Taiwan.Goals: To determine the prevalence and risk factors of NAFLD in an adult population of Taiwan.Study: The cross-sectional community study examined 3245 adults in a rural village of Taiwan. The diagnostic criteria for NAFLD included no excessive alcohol intake, no chronic viral hepatitis, no known etiologies of liver disease, and ultrasonography consistent with fatty liver.Results: The prevalence of NAFLD was 11.5% (372/3245). The risk factors for NAFLD in the general population were male sex [odds ratio (OR), 1.44; 95% confidence interval (CI), 1.09-1.90], elevated alanine aminotransferase (ALT) (OR, 5.66; 95% CI, 3.99-8.01), obesity (OR, 7.21; 95% CI, 5.29-9.84), fasting plasma glucose >= 126 mg/dL (OR, 2.08; 95% CI, 1.41-3.05), total cholesterol >= 240mg/dL (OR, 1.50; 95% CI, 1.06-2.13), triglyceride >= 150mg/dL (OR, 1.76; 95% CI, 1.32-2.35), and hyperuricemia (OR, 1.53; 95% CI, 1.16-2.01). Age >= 65 years was inversely related to NAFLD (OR, 0.53; 95% CI, 0.36-0.77). The only NAFLD risk factors among nonobese subjects were age between 40 and 64 years (OR, 2.35; 95% CI, 1.34-4.11, P = 0.003), elevated ALT (OR, 15.45; 95% CI, 8.21-29.09, P < 0.001), and triglyceride 150 mg/dL (OR, 2.48; 95% CI, 1.42-4.32, P = 0.001). In subjects with NAFLD, the prevalence of elevated ALT in the presence of each metabolic risk factor, such as obesity, fasting plasma glucose >= 126mg/dL, total cholesterol >= 240 mg/dL, triglyceride >= 150 mg/dL, and hyperuricemia, did not differ from that of subjects with normal ALT levels.Conclusions: NAFLD is closely associated with elevated ALT, obesity, diabetes mellitus, hypercholesterolemia, hypertriglyceridemia, and hyperuricemia. Among the metabolic disorders,