A proline-based phosphine template for Staudinger ligation.
A proline-based phosphine template for Staudinger ligation.
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DOI：
10.1021/ol3022484
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发表时间：
2012-08
期刊：
影响因子：
5.2
通讯作者：
Chung-Min Park;W. Niu;Chunrong Liu;T. Biggs;Jiantao Guo;M. Xian
中科院分区：
文献类型：
--
作者：
Chung-Min Park;W. Niu;Chunrong Liu;T. Biggs;Jiantao Guo;M. Xian
据报道，基于脯氨酸的膦模板能够在温和条件下快速进行含叠氮化物底物的施陶丁格连接。该反应的二级速率常数为1.12 M(-1) s(-1)。预计基于脯氨酸的施陶丁格连接策略将成为生物缀合和基于脯氨酸的肽偶联的有用方法。
A proline-based phosphine template enabling a rapid Staudinger ligation of azide-containing substrates under mild conditions is reported. This reaction has a second-order rate constant of 1.12 M(-1) s(-1). It is expected that the proline-based Staudinger ligation strategy will be a useful method for bioconjugation and proline based peptide coupling.