Mg-protoporphyrin IX signaling in Cyanidioschyzon merolae Multiple pathways may involve the retrograde signaling in plant cells
Mg-protoporphyrin IX signaling in Cyanidioschyzon merolae Multiple pathways may involve the retrograde signaling in plant cells
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DOI：
10.4161/psb.4.12.10061
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发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
Tanaka, Kan
中科院分区：
文献类型：
--
作者：
Kanesaki, Yu;Kobayashi, Yuki;Tanaka, Kan
叶绿体和线粒体是植物细胞中的细胞器，被认为是从细菌的内生共生关系进化而来的。这些细胞器都有自己的基因组，从它们的祖先传下来，植物细胞的细胞器DNA复制(ODR)与核DNA复制(NDR)是协调的，因为在细胞周期进程中，ODR先于NDR。然而，这种协调的基本机制在很大程度上仍有待确定。最近，我们发现了一种四吡咯化合物--镁原卟啉IX(MG-Proto)，它是植物细胞中从细胞器到NDR的细胞周期协调者。1虽然MG-Proto被认为是调节叶绿体蛋白核基因转录的逆行叶绿体信号，但我们的结果表明核转录调控不参与南方红曲霉NDR的诱导。因此，我们对NDR调控的发现可能代表了一种独立于传统的叶绿体信号的新的信号机制，我们将其命名为“寄生信号”，并提示了参与镁原信号的多条叶绿体-细胞核逆行信号途径。
Plastids and mitochondria are organelles in plant cells, which are considered to have evolved from endosymbiotic associations of bacteria. These organelles have their own genomes descended from their ancestors, and the organelle DNA replications (ODR) of plant cells are coordinated with the nuclear DNA replication (NDR) as ODR precedes NDR during a cell cycle progression. However, the underlying mechanism for this coordination remains largely to be determined. Recently, we identified that a tetrapyrrole compound, Mg-Protoporphyrin IX (Mg-Proto), is a cell cycle coordinator from organelle to NDR in plant cells. 1 While Mg-Proto has been suggested to be a retrograde plastid signal to modulate transcription of nuclear genes for plastid proteins, our results indicated that nuclear transcriptional regulation is not involved in the NDR induction in C. merolae. Thus, our finding for the NDR control is likely to represent a novel signaling mechanism independent of the conventional plastid signal, which we named "parasitic signal", and suggests multiple Mg-Protoinvolved pathways for the plastid-nucleus retrograde signaling.