The effects of the phyllolitorin analogue [desTrp3,Leu8]phyllolitorin on scratching induced by bombesin and related peptides in rats
The effects of the phyllolitorin analogue [desTrp3,Leu8]phyllolitorin on scratching induced by bombesin and related peptides in rats
复制标题
DOI：
10.1016/s0006-8993(99)01708-4
复制
发表时间：
1999-08-21
期刊：
影响因子：
2.9
通讯作者：
Woods, JH
中科院分区：
文献类型：
--
作者：
Johnson, MD;Ko, MC;Woods, JH
蛙皮素沿着几种密切相关的神经肽在中枢给药时引起抓挠行为。该研究的第一部分旨在确定一种新型叶下皂甙类似物[desTrp（3），Leu（8）]叶下皂甙（DTP）对三种肽（铃蟾肽、神经介素-C和[Leu（8）]叶下皂甙）诱导的抓挠的拮抗作用。此外，测定了每种肽对蛙皮素受体位点的结合亲和力。DTP（30 μ g）抑制由这些肽诱导的抓挠，但与肽不同，DTP对蛙皮素位点没有亲和力，从而表明DTP通过未知的机制显示生理拮抗作用。(C)1999 Elsevier Science B. V.保留所有权利。
Bombesin along with several closely related neuropeptides elicit scratching behavior when administered centrally. The first part of the study was designed to determine the antagonistic effects of a novel phyllolitorin analogue [desTrp(3),Leu(8)]phyllolitorin (DTP) on scratching induced by three peptides (bombesin, neuromedin-C, and [Leu(8)]phyllolitorin). In addition, the binding affinity of each peptide for the bombesin receptor site was determined. DTP (30 mu g) inhibited scratching induced by these peptides, but unlike the peptides, DTP had no affinity for the bombesin site, thereby suggesting that DTP is displaying physiological antagonism through an unknown mechanism. (C) 1999 Elsevier Science B.V. All rights reserved.