Miconazole lacquer in the treatment of denture stomatitis: clinical and microbiological findings in Chinese patients.
Miconazole lacquer in the treatment of denture stomatitis: clinical and microbiological findings in Chinese patients.
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DOI：
10.1007/s007840050008
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发表时间：
1997-02-01
影响因子：
3.4
通讯作者：
Lee, M T
中科院分区：
文献类型：
--
作者：
Dias, A P;Samaranayake, L P;Lee, M T
目的：探讨咪康唑漆在中国人群中治疗念珠菌相关性义齿口炎的临床疗效和真菌学疗效，并对其微生物学进行研究。设计：横断面研究口腔假丝酵母菌相关性口炎的临床、微生物学特征及治疗反应。分别于第0、7、14天进行临床检查、印迹培养、上颌骨照片监测治疗反应、上颌义齿基托涂漆，第21天复查印迹和照片，印迹培养采用图像分析方法进行量化。主要观察指标：病变严重程度、发病时和治疗期间微生物的发生率和类型；酵母菌生长的定性和定量评估；后者通过酵母菌落像素单位的统计分析；临床和真菌治疗的相关性。结果：在21个病变(16个牛顿氏I期和5个II期)中，57%的病变在出现时有酵母菌，10%的大肠菌群和33%的病变没有明显的生长。临床治愈在3周内占71%，真菌学治愈在7天内占75%，临床和真菌学治愈符合率仅为43%。结论：咪康唑漆是治疗中国人群中念珠菌相关性义齿口炎的一种可行的治疗方法；微生物包括酵母菌，主要是白色念珠菌和大肠菌群，尤其是克雷伯氏菌和肠杆菌；后者的致病作用值得怀疑。
OBJECTIVE: To investigate the efficacy of a miconazole lacquer in producing mycological and clinical cure of Candida-associated denture stomatitis in a Chinese cohort and to study the microbiology of the conditions.DESIGN: A cross-sectional study of the clinical and microbiological features of the condition and its response to treatment with the lacquer.SUBJECTS AND METHOD: Twenty-one Chinese adults with palatal erythema; 15 denture wearers matched for age and sex as controls for microbiology. Clinical examination, impression for culture, photograph of palate to monitor response to treatment, and lacquer application on upper denture base on days 0, 7 and 14. Impression and photograph repeated on day 21; impression cultures quantified by image analysis. Palatal impression in controls; dummy impression as control for impression culture procedures.MAIN OUTCOME MEASURES: Severity of lesion, incidence and type of microorganism at presentation and during treatment; qualitative and quantitative assessment of yeast growth; the latter by statistical analysis of pixel units of yeast colonies; correlation of clinical and mycological cure.RESULTS: Out of the 21 lesions (16 Newton's stage I and 5 stage II), 57% had yeasts at presentation, 10% coliforms and 33% no significant growth. Clinical cure in 3 weeks in 71%, mycological cure in 75% in 7 days; clinical and mycological cure coincided only in 43%. Polymicrobial growth of yeasts and coliforms throughout the course in some.CONCLUSIONS: Miconazole lacquer was a viable treatment option for Candida-associated denture stomatitis in this adult, Chinese cohort; microbiology comprised yeasts, mainly C. albicans and coliforms, especially Klebsiella and Enterobacter species; the pathogenic role of the latter is questionable.