Evolution of meristem zonation by CLE gene duplication in land plants
Evolution of meristem zonation by CLE gene duplication in land plants
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DOI：
10.1038/s41477-022-01199-7
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发表时间：
2022-07-19
期刊：
影响因子：
18
通讯作者：
Hirakawa, Yuki
中科院分区：
文献类型：
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作者：
Hirakawa, Yuki
CLE肽控制分生组织中的干细胞活性。最近对麻地兰和拟南芥的研究支持CLE肽的祖先功能是促进干细胞形成的观点。在被子植物中，经过基因复制后，一部分CLE肽成为干细胞抑制因子。在被植物中，一条涉及CLAVATA3 （CLV3）肽和WUSCHEL转录因子的负反馈通路维持着茎尖分生组织的干细胞数量，对茎的持续生长和器官发生至关重要。一个有趣的问题是，这种细胞信号系统是如何在陆地植物的进化过程中建立起来的。本文基于最近对CLV3/ esr相关基因（CLE）的两项研究，提出了分生组织分带进化的模型。该模型表明，限制干细胞的CLV3通路来源于在被子植物谱系中通过基因复制保守的促进干细胞的CLE通路。该模型可以在未来通过对不同植物物种的基因组和发育研究进行检验。
CLE peptides control stem-cell activity in meristems. Recent studies in Marchantia and Arabidopsis support the idea that an ancestral function of CLE peptides was to promote stem cells. After gene duplication in angiosperms, a subset of CLE peptides became stem-cell suppressors.In angiosperms, a negative feedback pathway involving CLAVATA3 (CLV3) peptide and WUSCHEL transcription factor maintains the stem-cell population in the shoot apical meristem and is central for continued shoot growth and organogenesis. An intriguing question is how this cell-signalling system was established during the evolution of land plants. On the basis of two recent studies on CLV3/ESR-related (CLE) genes, this paper proposes a model for the evolution of meristem zonation. The model suggests that a stem-cell-limiting CLV3 pathway is derived from stem-cell-promoting CLE pathways conserved in land pants by gene duplication in the angiosperm lineage. The model can be examined in the future by genomic and developmental studies on diverse plant species.