Recovery of fear memories in rats: Role of gamma-amino butyric acid (GABA) in infantile amnesia
Recovery of fear memories in rats: Role of gamma-amino butyric acid (GABA) in infantile amnesia
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DOI：
10.1037/0735-7044.120.1.40
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发表时间：
2006-02-01
影响因子：
1.9
通讯作者：
Richardson, R
中科院分区：
文献类型：
--
作者：
Kim, JH;McNally, GP;Richardson, R
婴儿健忘症是一种普遍存在的现象，但其神经基础在很大程度上仍然未知。作者确定了GABA能传递在抑制婴儿期获得的记忆恢复中的作用。18日龄的大鼠接受成对的白色噪音和电击; 10天后发生了相当大的遗忘（通过冻结评估）。在训练后10天，而不是2个月，通过预先给予GABA（A）反向激动剂FG 7142恢复记忆。当使用被动回避程序时，FG 7142的这种作用普遍化。此外，FG 7142减少了对潜在抑制条件刺激的恐惧，表明观察到的记忆恢复效果不是由于状态依赖性过程。看来，GABA可能参与婴儿健忘症，无论记忆的情感内容。
Infantile amnesia is a ubiquitous phenomenon, but its neural bases remain largely unknown. The authors identify a role for GABAergic transmission in suppressing retrieval of memories acquired in infancy. Eighteen-day-old rats received pairings of white noise and shock; considerable forgetting of this experience (assessed by freezing) occurred after 10 days. The memory was recovered by pretest administration of the GABA(A) inverse agonist FG7142 10 days, but not 2 months, after training. This effect of FG7142 generalized when a passive avoidance procedure was used. Also, FG7142 decreased fear of a latently inhibited conditioned stimulus, showing that the observed memory recovery effect was not due to a state-dependent process. It appears that GABA may be involved in infantile amnesia regardless of the emotional content of the memory.