Soy isoflavones modulate adipokines and myokines to regulate lipid metabolism in adipose tissue, skeletal muscle and liver of male Huanjiang mini-pigs
Soy isoflavones modulate adipokines and myokines to regulate lipid metabolism in adipose tissue, skeletal muscle and liver of male Huanjiang mini-pigs
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DOI：
10.1016/j.mce.2012.09.002
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发表时间：
2013-01
影响因子：
4.1
通讯作者：
Huansheng Yang;Fengna Li;X. Xiong;X. Kong;Bin Zhang;Xiaoxue Yuan;Juexin Fan;Y. Duan;M. Geng-M.-G
中科院分区：
文献类型：
--
作者：
Huansheng Yang;Fengna Li;X. Xiong;X. Kong;Bin Zhang;Xiaoxue Yuan;Juexin Fan;Y. Duan;M. Geng-M.-G
虽然越来越多的证据表明大豆异黄酮有助于调节脂质代谢，但其潜在机制尚未完全阐明。本研究旨在探讨大豆异黄酮对环江小型猪不同脂肪组织库、骨骼肌和肝脏脂质代谢相关基因表达以及脂肪因子和肌因子表达的影响。选用36头环江小型猪，分别饲喂基础日粮（Con）、低剂量大豆异黄酮（LSI）和高剂量大豆异黄酮（HSI）。结果表明，LSI和HSI对背皮下脂肪（DSA）、腹皮下脂肪（阿萨）、肾周脂肪（PRA）、背最长肌（LDM）和肝脏中脂肪酸合成和释放相关基因的表达具有调控作用。LSI和HSI还调节雄性环江小型猪DSA、阿萨和PRA中脂肪因子的表达，以及LDM中肌因子的表达。此外，大豆异黄酮治疗2个月后可调节血糖、瘦素和脂联素含量。我们的研究结果表明，大豆异黄酮，通过调节脂肪因子和肌因子的表达，可以调节脂质代谢，并可能有潜在的治疗应用在血脂异常。
Although a growing body of evidence suggests that soy isoflavones help regulate lipid metabolism, the underlying mechanism has not yet been thoroughly clarified. The present study was undertaken to determine the effects of soy isoflavones on the expression of genes involved in lipid metabolism in different adipose tissue depots, skeletal muscle and liver of male Huanjiang mini-pigs, as well as the expression of adipokines and myokines. A total of 36 male Huanjiang mini-pigs were fed basal diet (control, Con), low-dose soy isoflavones (LSI) and high-dose soy isoflavones (HSI). The results showed that LSI and HSI regulated the expression of genes involved in the anabolism and catabolism of fatty acids in dorsal subcutaneous (DSA), abdominal subcutaneous (ASA) and perirenal (PRA) adipose tissue depots, as well as longissimus dorsi muscle (LDM) and liver. LSI and HSI also regulated the expression of adipokines in DSA, ASA and PRA, and the expression of myokines in LDM in male Huanjiang mini-pigs. In addition, soy isoflavones regulated plasma glucose, leptin and adiponectin contents after treatment for two months. Our results indicate that soy isoflavones, by regulating the expression of adipokines and myokines, may regulate the metabolism of lipids and could have potential therapeutic applications in lipid abnormalities.