Nonenzymatic kinetic resolution of 1,2-diols catalyzed by an organotin compound
Nonenzymatic kinetic resolution of 1,2-diols catalyzed by an organotin compound
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DOI：
10.1021/ol9908373
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发表时间：
1999-10-07
期刊：
影响因子：
5.2
通讯作者：
Matsumura, Y
中科院分区：
文献类型：
--
作者：
Iwasaki, F;Maki, T;Matsumura, Y
[图表]开发了一种新的使用手性有机锡催化剂A与苯甲酰氯的1，2-二醇1的非酶动力学拆分方法。观察到由于无机碱如碳酸钠和少量水对主产物2的ee的显著影响。该反应对1，2-二醇表现出高的对映选择性和化学选择性1。
[GRAPHICS]A new nonenzymatic kinetic resolution method of 1,2-diols 1 using chiral organotin catalyst A with benzoyl chloride was developed. A remarkable effect due to an inorganic base such as sodium carbonate and a small portion of water on the ee of the main products 2 was observed. The reaction showed high enantio- and chemoselectivities to 1,2-diols 1.