Polypoidal choroidal vasculopathy with choroidal vascular hyperpermeability
Polypoidal choroidal vasculopathy with choroidal vascular hyperpermeability
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DOI：
10.1016/j.ajo.2006.05.051
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发表时间：
2006-10-01
影响因子：
4.2
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
--
作者：
Sasahara, Manabu;Tsujikawa, Akitaka;Yoshimura, Nagahisa
目得：描述与脉络膜血管通透性过高相关的息肉状脉络膜血管病（PCV）的发病率和临床特征。设计：回顾性观察病例系列。方法：我们回顾了连续122只患有PCV的眼睛和连续106只患有渗出性年龄、相关性黄斑变性（AMD）的眼睛的医疗记录。采用激光共聚焦扫描系统进行血管造影和吲哚菁绿色（ICG）血管造影。在ICG血管造影的中期，我们评估了脉络膜血管通透性过高，这被认为是中心性浆液性脉络膜视网膜病变（CSC）的特征性表现之一。脉络膜血管通透性过高表现为脉络膜内多灶性斑片状高荧光区，边缘模糊，注射染料后强度随时间增加。122只患眼中，12只眼10例（9.8%）患者的眼在ICG血管造影中期出现多灶性脉络膜高荧光，而106只渗出型AMD中有2只（1.9%）表现出相似的外观（P = 0.013）。在10例PCV患者的12只眼中，我们还注意到ICG血管造影早期显示7只眼（58%）脉络膜充盈延迟和12只眼（100%）静脉扩张。这12只眼睛（33%）有CSC的病史，和9（90%）的10例患者显示多灶性脉络膜荧光bilateral.CONCLUSIONS：多灶性脉络膜荧光可见ICG血管造影发生更频繁的PCV比那些与AMD的眼睛。脉络膜血管通透性增高是CSC的特征性表现，可能是PCV的危险因素之一。
PURPOSE: To describe the incidence and clinical characteristics of polypoidal choroidal vasculopathy (PCV) associated with choroidal vascular hyperpermeability.DESIGN: Retrospective observational case series.METHODS: We reviewed the medical records of 122 consecutive eyes with PCV and 106 consecutive eyes with exudative age,related macular degeneration (AMD). Fluorescein angiography and indocyanine green (ICG) angiography were performed using a confocal scanning laser system. In the midphase of ICG angiography, we evaluated choroidal vascular hyperpermeability, which is recognized as one of the characteristic findings in central serous chorioretinopathy (CSC). Choroidal vascular hyperpermeability appeared as multifocal patchy areas of hyperfluorescence with blurred margins within the choroid that increased in intensity with time after injection of the dye.RESULTS: Of 122 eyes with PCV, 12 (9.8%) eyes of 10 patients exhibited multifocal choroidal hyperfluorescence in the midphase of ICG angiography, whereas two (1.9%) of 106 eyes with exudative AMD showed a similar appearance (P = .013). Of the 12 eyes in 10 patients with PCV that demonstrated multifocal choroidal hyperfluorescence, we also noted that the early phase of ICG angiography showed choroidal filling delay in seven eyes (58%) and venous dilation in 12 eyes (100%). Four of these 12 eyes (33%) had a medical history of CSC, and nine (90%) of the 10 patients revealed multifocal choroidal hyperfluorescence bilaterally.CONCLUSIONS: Multifocal choroidal hyperfluorescence seen by ICG angiography occurs more frequently in eyes with PCV than in those with AMD. Choroidal vascular hyperpermeability, reportedly a characteristic finding in CSC, might be one of the risk factors of PCV.