A HEMEOBOX GENE ESSENTIAL FOR ZEBRAFISH NOTOCHORD DEVELOPMENT
A HEMEOBOX GENE ESSENTIAL FOR ZEBRAFISH NOTOCHORD DEVELOPMENT
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DOI：
10.1038/378150a0
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发表时间：
1995-11-09
期刊：
影响因子：
64.8
通讯作者：
KIMELMAN, D
中科院分区：
文献类型：
--
作者：
TALBOT, WS;TREVARROW, B;KIMELMAN, D
脊索是一种中线中胚层结构，在所有脊椎动物胚胎中具有重要的构图功能。斑马鱼浮头突变体缺乏脊索，但具有前脊索板和其他中胚层衍生物，这表明Flh在脊索发育中具有特殊功能。我们证明浮头是斑马鱼Xnot的同源基因，Xnot是一种在两栖动物组织者和脊索中表达的同源盒基因。我们认为，Flh调控脊索前体细胞的命运。
The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head Is the zebrafish homologue of Xnot, a homeobox gene expressed In the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.