MULTIPLE CARCINOMAS OF LARGE BOWEL - NATURAL EXPERIMENT IN ETIOLOGY AND PATHOGENESIS
MULTIPLE CARCINOMAS OF LARGE BOWEL - NATURAL EXPERIMENT IN ETIOLOGY AND PATHOGENESIS
复制标题
DOI：
10.1097/00000658-197801000-00002
复制
发表时间：
1978-01-01
影响因子：
9
通讯作者：
DRAGACEVIC, S
中科院分区：
文献类型：
--
作者：
ENKER, WE;DRAGACEVIC, S
研究了2例或2例以上大肠癌患者[121]。对异时性疾病患者中第二种癌症发生部位的评价支持了这样一种观点，即向结肠输送的胆汁酸增加可能在肿瘤发病机制中发挥作用。由于异时性疾病患者中晚期肿瘤的发生率极高，应尽一切努力确定那些应该接受预防性全腹结肠切除术的患者。需要具有更高灵敏度的更新方法来改善易于发生第二大肠肿瘤的患者的随访。
Patients [121] with 2 or more large bowel cancers were studied. An evaluation of the site of incidence of 2nd cancers in patients presenting with metachronous disease supports the concept that increased delivery of bile acids to the colon may play a role in tumor pathogenesis. Because of the extremely high incidence of advanced tumors in patients with metachronous disease, every effort should be made to identify those patients who should undergo a preventive total abdominal colectomy. Newer methods with increased sensitivity are required to improve the follow-up of patients who are prone to develop 2nd neoplasms of the large bowel.