USE OF SINGLE VOIDED URINE SAMPLES TO ESTIMATE QUANTITATIVE PROTEINURIA
USE OF SINGLE VOIDED URINE SAMPLES TO ESTIMATE QUANTITATIVE PROTEINURIA
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DOI：
10.1056/nejm198312223092503
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
GARELLA, S
中科院分区：
文献类型：
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作者：
GINSBERG, JM;CHANG, BS;GARELLA, S
尿蛋白排泄的定量被广泛用于诊断和预后目的，并评估治疗效果。最常用于测量尿蛋白的方法依赖于24小时尿液收集，这是耗时的，繁琐的，并且通常不准确。单次排尿样本中的尿蛋白/肌酐比值应与定时尿液采集中的蛋白质量密切相关。在一项对46份样本的研究中，发现24小时尿液采集的蛋白质含量与单个尿液样本中的蛋白质/肌酐比值之间存在良好的相关性。最好的相关性被发现时，样品收集后，第一次排尿的早晨标本和睡前。当考虑到不同肌酐排泄率的影响时，在正常日光活动期间获得的单个尿液样本中测定蛋白/肌酸比率，可以在临床定量蛋白尿中取代24小时尿液收集。在肾功能稳定的情况下，蛋白质/肌酐比值> 3.5（mg/mg）可以被认为是肾病范围的蛋白尿，比值< 0.2是在正常范围内。
Quantitation of urinary protein excretion is used extensively for diagnostic and prognostic purposes and to assess the effects of therapy. The method most commonly used to measure urinary protien relies on 24 h urine collections, which are time consuming, cumbersome, and often inaccurate. The urinary protein/creatinine ratio in a single voided urine sample should correlate well with the quantity of protein in timed urine collections. In a study of 46 specimens an excellent correlation was found between the protein content of a 24-h urine collection and the protein/creatinine ratio in a single urine sample. The best correlation was found when samples were collected after the 1st voided morning specimen and before bedtime. The determination of the protein/creatine ratio in single urine samples obtained during normal daylight activity, when properly interpreted by taking into consideration the effect of different rates of creatinine excretion, can replace the 24-h urine collection in the clinical quantitation of proteinuria. In the presence of stable renal function, a protein/creatinine ratio of > 3.5 (mg/mg) can be taken to represent nephrotic-range proteinuria, and a ratio < 0.2 is within normal limits.