Epigenetic modulation at the CCR2 gene correlates with the maintenance of behavioral sensitization to methamphetamine
Epigenetic modulation at the CCR2 gene correlates with the maintenance of behavioral sensitization to methamphetamine
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DOI：
10.1111/j.1369-1600.2010.00219.x
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发表时间：
2010-07-01
影响因子：
3.4
通讯作者：
Suzuki, Tsutomu
中科院分区：
文献类型：
--
作者：
Ikegami, Daigo;Narita, Minoru;Suzuki, Tsutomu
间歇性服用甲基苯丙胺会产生对甲基苯丙胺的行为过敏。在间歇性接受甲基苯丙胺治疗的小鼠的边缘前脑（主要包括伏隔核）中，我们发现趋化因子 CCR2 的 mRNA 显着增加。这种增加伴随着其启动子处组蛋白 H3 赖氨酸 4 (H3K4) 三甲基化的显着增加。有趣的是，CCR2 敲除小鼠对甲基苯丙胺诱导的过度运动的敏感性维持显着降低。这些发现表明，间歇性服用甲基苯丙胺后与表观遗传修饰相关的 CCR2 增加可能与维持对甲基苯丙胺诱导的过度运动的敏感性有关。
The intermittent administration of methamphetamine produces behavioral sensitization to methamphetamine. In the limbic forebrain, mainly including the nucleus accumbens, of mice that had been intermittently treated with methamphetamine, we found a significant increase in mRNA of a chemokine, CCR2. This increase was accompanied by a significant increase in histone H3 lysine 4 (H3K4) trimethylation at its promoter. Interestingly, the maintenance of sensitization to methamphetamine-induced hyperlocomotion was significantly decreased in CCR2 knockout mice. These findings suggest that increased CCR2 associated with epigenetic modification after the intermittent administration of methamphetamine may be associated with the maintenance of sensitization to methamphetamine-induced hyperlocomotion.