MEMBRANE TRAFFICKING ALONG THE PHAGOCYTIC PATHWAY
MEMBRANE TRAFFICKING ALONG THE PHAGOCYTIC PATHWAY
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DOI：
10.1016/s0962-8924(00)88958-8
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发表时间：
1995-03-01
影响因子：
19
通讯作者：
STAHL, PD
中科院分区：
文献类型：
--
作者：
BERON, W;ALVAREZDOMINGUEZ, C;STAHL, PD
吞噬体成熟涉及到吞噬体膜的广泛重塑，这是细胞内运输事件的结果。新形成的吞噬体通过融合与早期内体交换膜相关蛋白和可溶性蛋白。吞噬体中囊泡的出芽和与高尔基衍生囊泡的融合也可能有助于吞噬体腔室的重塑。由于膜组成的改变，吞噬体获得了与晚期内吞室融合的能力。体外重构和其他研究表明，吞噬体成熟背后的转运事件需要几种gtp结合蛋白，包括Rab5和G(α s)， NSF-SNAP-SNARE复合物和涂层。
Phagosome maturation involves extensive remodelling of the phagosomal membrane as a result of intracellular transport events. Newly formed phagosomes exchange membrane-associated and soluble proteins with early endosomes by fusion. Budding of vesicles from the phagosome and fusion with Golgi-derived vesicles may also contribute to the remodelling of the phagosomal compartment. As a consequence of changes in membrane composition, phagosomes acquire the ability to fuse with late endocytic compartments. In vitro reconstitution and other studies suggest that the trafficking events underlying phagosome maturation require several GTP-binding proteins, including Rab5 and G(alpha s), NSF-SNAP-SNARE complexes and coatomers.