Hippocampal atrophy is related to impaired memory, but not frontal functions in non-demented Parkinson's disease patients
Hippocampal atrophy is related to impaired memory, but not frontal functions in non-demented Parkinson's disease patients
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DOI：
10.1097/00001756-199805110-00048
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发表时间：
1998-05-11
期刊：
影响因子：
1.7
通讯作者：
Riekkinen, M
中科院分区：
文献类型：
--
作者：
Riekkinen, P;Kejonen, K;Riekkinen, M
我们研究了帕金森病（PD）患者海马萎缩的神经心理学相关因素。记忆受损PD患者的海马比其他PD患者小。PD患者在空间工作记忆和注意集转移方面的表现与运动缺陷严重程度相关，而与海马萎缩无关。我们的研究结果表明，言语/视觉记忆的失败可能与帕金森病的海马萎缩有关。而空间工作记忆和注意集转移的缺陷可能与PD患者额纹状体功能障碍有关。(C) 1998快速科学有限公司
WE investigated the neuropsychological correlates of hippocampal atrophy in Parkinson's disease (PD) patients. The memory impaired PD patients had smaller hippocampi than other PD patients. The performance of PD patients in spatial working memory and attentional set-shifting correlated with the severity of motor defect, and not with hippocampal atrophy. Our results suggests that failure of verbal/visual memory may be related to hippocampal atrophy in Parkinson's disease. On the contrast, the defect in spatial working memory and attentional set-shifting may be sensitive to dysfunction of 'fronto-striatal' systems in PD patients. (C) 1998 Rapid Science Ltd.