Natural Products and Derivatives as Leads to Cell Cycle Pathway Targets in Cancer Chemotherapy
Natural Products and Derivatives as Leads to Cell Cycle Pathway Targets in Cancer Chemotherapy
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DOI：
10.2174/1568009023333791
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发表时间：
2002-01-01
影响因子：
3
通讯作者：
Sausville, Edward A.
中科院分区：
文献类型：
--
作者：
Newman, David J.;Cragg, Gordon M.;Sausville, Edward A.
天然产物对药物发现的影响总体上是相当令人印象深刻的；人们只需查看用于癌症治疗的临床活性药物的数量，就可以看出其中有多少是天然产物或具有天然产物药效团。现在变得非常明显的是，来自自然来源的材料是细胞靶标的极好探针(指示器)，当被调节时，很可能会对肿瘤细胞在常规细胞周期中的循环产生有害影响。如果特定靶点在正常的细胞周期中没有表达，那么对肿瘤细胞周期的直接“干扰”很可能导致一种针对特定肿瘤类型的新的治疗方法。在这篇综述中，我们没有试图穷尽，但已经给出了来自海洋、微生物和植物来源的天然产品如何允许在不同条件下对细胞周期的不同部分进行深入分析的最新概述，最终目的是试图以一种允许通过细胞死亡最终清除肿瘤细胞的方式来“控制或干扰”肿瘤细胞的循环，同时对宿主造成最小的创伤。
The influence of natural products upon drug discovery in general has been quite impressive; one only has to look at the number of clinically active drugs that are in use in cancer therapy to see how many either are natural products or have a natural product pharmacophore. What is now becoming quite apparent is that materials from natural sources are excellent probes (indicators) for cellular targets that when modulated, may well have a deleterious effect upon the cycling of a tumor cell through the conventional cell cycle. If the particular target is not expressed in normal cell cycling, then a directed "perturbation" of the tumor cell's cycle may well lead to a novel method of treatment for specific tumor types. In this review we have not attempted to be exhaustive but have given a current overview of how natural products from marine, microbial and plant sources have permitted in-depth analyses of various parts of the cell cycle under varying conditions with the ultimate aims of attempting to "control or perturb" the cycling of tumor cells in a fashion that permits their ultimate removal via cellular death, with a minimum of trauma to the host.