Innate and virtual memory T cells in man.
Innate and virtual memory T cells in man.
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人类先天和虚拟记忆 T 细胞。
DOI：
10.1002/eji.201545761
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发表时间：
2015
影响因子：
5.4
通讯作者：
VanKaer,Luc
中科院分区：
文献类型：
--
作者：
VanKaer,Luc
适应性免疫系统的抗原特异性B和T淋巴细胞的一个标志是它们在首次遇到病原体后很长时间内“记住”病原体的能力，这一特性构成了有效疫苗开发的基础。然而，在小鼠中的研究提供了强有力的证据，表明一些幼稚T细胞可以在没有外来抗原遭遇的情况下发展记忆T细胞的特征。这种先天记忆T细胞可能会在淋巴细胞减少症或高水平细胞因子IL-4的存在下发育，并且也已在未经操作的动物中被鉴定，这一现象被称为“虚拟记忆”。虽然先天记忆T细胞在小鼠中的存在现在被广泛接受，但它们在人类中的存在尚未得到充分验证。在这一期的《欧洲免疫学杂志》上，Jacomet et et al. [Eur. J. Immunol. 2015. 45：1926 - 1933]提供了迄今为止人类先天记忆T细胞的最佳证据。这些发现可能有助于我们了解人类对微生物病原体和肿瘤的免疫力。
A hallmark of the antigen‐specific B and T lymphocytes of the adaptive immune system is their capacity to “remember” pathogens long after they are first encountered, a property that forms the basis for effective vaccine development. However, studies in mice have provided strong evidence that some naive T cells can develop characteristics of memory T cells in the absence of foreign antigen encounters. Such innate memory T cells may develop in response to lymphopenia or the presence of high levels of the cytokine IL‐4, and have also been identified in unmanipulated animals, a phenomenal referred to as “virtual memory.” While the presence of innate memory T cells in mice is now widely accepted, their presence in humans has not yet been fully validated. In this issue of theEuropean Journal of Immunology, Jacomet et al. [Eur. J. Immunol. 2015. 45:1926‐1933] provide the best evidence to date for innate memory T cells in humans. These findings may contribute significantly to our understanding of human immunity to microbial pathogens and tumors.