Characterization and adsorptive properties of pharmaceutical grade clays.
Characterization and adsorptive properties of pharmaceutical grade clays.
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药用级粘土的表征和吸附性能。
DOI：
10.1002/jps.2600690719
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发表时间：
1980
影响因子：
3.8
通讯作者：
S. Hem
中科院分区：
文献类型：
--
作者：
J. Browne;J. Feldkamp;J. White;S. Hem
如果确定了商品粘土样品的特性和性质，就可以预测制药常用粘土对四环素的吸附。x射线衍射。用红外光谱和化学分析方法鉴定了一系列商业制药级粘土中的粘土成分和任何非粘土稀释剂。粘土的主要成分为蒙脱土、英脱石、凹凸棒石、皂土和高岭石。粘土的结构、交换阳离子的性质和非粘土组分的存在是影响四环素-粘土相互作用的重要因素。一般来说，具有高表面电荷的粘土结构导致与质子化形式的四环素的更大相互作用，而与四环素的两性离子形式的相互作用发生在具有最小表面电荷的粘土结构中。粘土表面多价、可交换阳离子的存在减少了与四环素质子化形式的相互作用。非粘土组分，如方解石和白云石，增加了四环素的两性离子和阴离子形式与粘土的相互作用。
The adsorption of tetracycline by clays commonly used in pharmacy can be predicted if the identity and character of the commerical clay sample are established. X-ray diffraction. IR spectroscopy, and chemical analysis were used to identify the clay component and any nonclay diluents present in a series of commerical pharmaceutical grade clays. The major clay components were montmorillonite, hectorite, attapulgite, saponite, and kaolinite. The clay structure, the nature of the exchangeable cation, and the presence of nonclay components are important factors affecting the tetracycline-clay interaction. In general, clay structures with a high surface charge lead to a greater interaction with the protonated form of tetracycline, while interaction with the zwitterionic form of tetracycline occurs in clay structures with minimal surface charge. The presence of multivalent, exchangeable cations on the clay surface diminishes interaction with the protonated form of tetracycline. Nonclay components such as calcite and dolomite increase the interactions of the zwitterionic and anionic forms of tetracycline with the clay.