High prevalence of sleep disturbance in cirrhosis
High prevalence of sleep disturbance in cirrhosis
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DOI：
10.1002/hep.510270204
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发表时间：
1998-02-01
期刊：
影响因子：
13.5
通讯作者：
Blei, AT
中科院分区：
文献类型：
--
作者：
C贸rdoba, J;Cabrera, J;Blei, AT
睡眠障碍是肝性脑病的一个典型体征，但关于无明显肝性脑病的睡眠障碍患者的患病率的数据有限。我们使用睡眠问卷（n = 44）和体动仪（n = 20）评估了肝硬化患者的睡眠特征。并与慢性肾功能衰竭患者及健康对照组进行比较。亚临床肝性脑病的存在，时间型配置文件，和个人的情感状态进行了分析。问卷调查显示，与健康对照组（4.5%，P <0.01）相比，抱怨睡眠不满意的糖尿病患者（47.7%）和慢性肾功能衰竭患者（38.6%）的数量增加。运动描记术证实睡眠不满意的癫痫患者的睡眠参数恶化。肝硬化患者的睡眠障碍与临床参数和认知功能障碍无关。肝硬化受试者和睡眠不满意的慢性肾功能衰竭患者的抑郁和焦虑评分较高，提高了慢性疾病的影响可能是睡眠障碍发病机制的基础。然而，与慢性肾功能衰竭相反，肝硬化患者睡眠不满意与就寝时间延迟、起床时间延迟和夜间时间类型有关。总之，睡眠障碍是常见的肝性脑病患者无，可能与昼夜节律计时系统的异常。
Sleep disturbance is a classic sign of hepatic encephalopathy, However, there are limited data regarding its prevalence in cirrhotic patients without overt hepatic encephalopathy. We assessed the characteristics of sleep in cirrhosis using a sleep questionnaire (n = 44) and actigraphy (n = 20). The results were compared with those of subjects with chronic renal failure and those of healthy controls. Presence of subclinical hepatic encephalopathy, chronotypology profile, and individual's affective state were also analyzed. The questionnaire indicated an elevated number of cirrhotic patients (47.7%) and patients with chronic renal failure (38.6%) who complained of unsatisfactory sleep compared with healthy controls (4.5%, P < .01). Actigraphy corroborated the deterioration of sleep parameters in cirrhotic patients with unsatisfactory sleep. The sleep disturbance in cirrhosis was not associated with clinical parameters nor with cognitive impairment. Cirrhotic subjects and patients with chronic renal failure with unsatisfactory sleep showed higher scores for depression and anxiety, raising the possibility that the effects of chronic disease may underlie the pathogenesis of sleep disturbance. However, in contrast to chronic renal failure, unsatisfactory sleep in cirrhosis was associated with delayed bedtime, delayed wake-up time, and evening chronotypology. In conclusion, a sleep disturbance is frequent in cirrhotic patients without hepatic encephalopathy and may be related to abnormalities of the circadian timekeeping system.