Prevalence of community-associated methicillin-resistant Staphylococcus aureus colonization in men who have sex with men
Prevalence of community-associated methicillin-resistant Staphylococcus aureus colonization in men who have sex with men
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DOI：
10.1258/ijsa.2008.008243
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发表时间：
2009-03-01
影响因子：
1.4
通讯作者：
Loutfy, M. R.
中科院分区：
文献类型：
--
作者：
Antoniou, T.;Devlin, R.;Loutfy, M. R.
由社区相关耐甲氧西林金黄色葡萄球菌（CA-MRSA）介导的皮肤和软组织感染的爆发在男男性行为者（MSM）中的报告频率越来越高。然而，这种微生物无症状定植在使这些感染永久化中的潜在作用尚不清楚。本横断面研究的目的是确定从加拿大多伦多两个内城诊所招募的500名MSM队列中CA-MRSA定植的患病率。在提供知情同意书后，受试者完成了一份问卷，收集可能与MRSA定植相关的人口统计学和临床变量。采集每例受试者的MRSA鼻拭子，并提供关于直肠拭子自我采集的说明。培养的MRSA进行脉冲场凝胶电泳和毒力测试Panton-Valentine杀白细胞素基因的表达。CA-MRSA定植率为1.6%（95% CI：0.5-2.6%）。
Outbreaks of skin and soft tissue infections mediated by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are being reported with increasing frequency among men who have sex with men (MSM). However, the potential role of asymptomatic colonization with this organism in perpetuating these infections is unclear. The purpose of this cross-sectional study was to determine the prevalence of colonization with CA-MRSA among a cohort of 500 MSM recruited from two inner city clinics in Toronto, Canada. Following the provision of informed consent, subjects completed a questionnaire capturing demographic and clinical variables, which may be associated with MRSA colonization. A nasal swab for MRSA was collected from each subject, and instructions were provided regarding the self-collection of a rectal swab. Cultured MRSA underwent pulsed-field gel electrophoresis and virulence testing for Panton-Valentine leukocidin gene expression. The prevalence of CA-MRSA colonization was 1.6% (95% CI: 0.5-2.6%).