Liver is a primary source of insulin-like growth factor-1 in skin wound healing.
Liver is a primary source of insulin-like growth factor-1 in skin wound healing.
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DOI：
10.1530/joe-21-0298
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发表时间：
2021-11-24
期刊：
影响因子：
--
通讯作者：
Koh TJ
中科院分区：
文献类型：
--
作者：
Roberts RE;Cavalcante-Silva J;Kineman RD;Koh TJ
Insulin-like growth factor (IGF)-1 plays important roles in tissue repair through its ability to stimulate wound cell activity. While IGF-1 is expressed locally by wound cells, liver-derived IGF-1 is also present at high levels in the circulation, and the contributions of local versus circulating IGF-1 to wound levels remain undefined. The hypothesis of this study was that liver is a primary source of IGF-1 during skin wound healing. To test this hypothesis, we utilized a model that allows inducible ablation of IGF-1 specifically in liver of adult mice. We demonstrate that ablation of liver IGF-1 leads to >85% loss of circulating IGF-1 and ~60% decrease in wound IGF-1 during the proliferative phase of healing in both male and female mice. This reduction of liver-derived IGF-1 did not alter local mRNA expression of IGF-1 in wounds. Knockdown of liver IGF-1 significantly delayed wound re-epithelialization, and reduced granulation tissue formation and collagen deposition. Knockdown of liver IGF-1 also significantly reduced angiogenesis and resulted in persistent macrophage accumulation. In summary, liver is a primary source of IGF-1 in skin wounds, and contributes to many aspects of both epithelial and dermal healing.
