Prenatal and perinatal risk factors for autism
Prenatal and perinatal risk factors for autism
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DOI：
10.1515/jpm.1999.059
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发表时间：
1999-01-01
影响因子：
2.4
通讯作者：
Klug, MG
中科院分区：
文献类型：
--
作者：
Burd, L;Severud, R;Klug, MG
目的：探讨孤独症的围产期危险因素.方法：病例对照研究.我们将来自北达科他州的符合DSM自闭症（一种广泛性发育障碍）和自闭症标准的患者姓名与他们的出生证明进行了匹配。结果：78例患者和390例对照者的单因素分析确定了7个危险因素。控制混杂因素的Logistic建模产生了一个五变量模型。模型参数为chi（2）= 36.6和p < 0.001。模型中的五个变量是出生体重下降，母亲受教育程度低，产前护理开始较晚，以及先前终止妊娠。增加父亲的年龄与增加的风险autosit.Conclusion：这种方法可以提供一种廉价的方法，诊所和公共卫生提供者，以确定危险因素，并确定母亲的精神疾病和发育障碍患者的特点。
Aim: To identify pre- and perinatal risk factors for autism.Method: Case control study. We matched names of patients from North Dakota who met DSM criteria for autism, a pervasive developmental disorder, and autistic disorder with their birth certificates. Five matched controls were selected for each case.Results: Univariate analysis of the 78 cases and 390 controls identified seven risk factors. Logistic modeling to control for confounding produced a five variable model. The model parameters were chi(2) = 36.6 and p < 0.001. The five variables in the model were decreased birth weight, low maternal education, later start of prenatal care, and having a previous termination of pregnancy. Increasing father's age was associated with increased risk of autism.Conclusion: This methodology may provide an inexpensive method for clinics and public health providers to identify risk factors and to identify maternal characteristics of patients with mental illness and developmental disorders.