Factors Influencing Long-Term Survival in Patients with T3 Gallbladder Adenocarcinoma
Factors Influencing Long-Term Survival in Patients with T3 Gallbladder Adenocarcinoma
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DOI：
10.1159/000210131
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发表时间：
2009-01-01
期刊：
影响因子：
3.2
通讯作者：
Chen, Miin-Fu
中科院分区：
文献类型：
--
作者：
Chakravarty, K. Dilip;Yeh, Chun-Nan;Chen, Miin-Fu
目的：探讨影响T3期胆囊腺癌(GBA)手术疗效的因素。方法：回顾1996-2006年间在台湾长庚医院接受手术治疗的100例GBA患者的临床资料。对其中39例病理分期为T3的GBA患者的人口学资料和临床病理特征进行统计分析。结果：手术治疗的T3GBA患者1、3、5年生存率分别为53.5%、37.0%和32.9%。单因素生存分析显示，男性、低血清癌胚抗原(CEA)水平和根治性切除是预测T3GBA患者总体生存良好的因素。多变量生存分析显示，术前CEA水平较低，根治性切除独立预测良好的预后。结论：阴性切缘和血清CEA水平是预测T3GBA患者长期生存的独立预后因素，血清CEA水平也是预测T0~T4GBA患者长期预后的独立预后因素，但由于患者数量有限，结果尚属初步。有必要对大量患者进行进一步研究，以证实我们的结果。版权所有(C)2009 S.Karger AG，巴塞尔
Purpose: This study aimed to identify the factors influencing the surgical outcome in patients with T3 gallbladder adenocarcinoma (GBA). Methods: Between 1996 and 2006, 100 GBA patients who underwent surgical treatment in Chang Gung Memorial Hospital, Taiwan, were retrospectively reviewed. Among them, 39 patients with pathological stage T3 GBA were analyzed statistically in terms of demographic data and clinicopathological features. Results: The 1-, 3- and 5-year survival rates for patients with T3 GBA undergoing surgical treatment were 53.5, 37.0 and 32.9%, respectively. Univariate survival analysis revealed male gender, low serum carcinoembryonic antigen (CEA) level, and curative resection as factors which predicted favorable overall survival for T3 GBA patients. Multivariate survival analysis revealed low preoperative CEA levels and curative resections independently predicted favorable outcomes. Conclusions: Negative resection margin and serum CEA levels were found to be the independent prognostic factors in predicting long-term survival in patients with T3 GBA, and the serum CEA level was also found to be an independent prognostic factor in predicting the long-term prognosis of T0-T4 GBA; however, the result is preliminary due to the limited number of patients. Further studies with a large number of patients are necessary to confirm our result. Copyright (C) 2009 S. Karger AG, Basel