Targeting of Proteins for Translocation at the Endoplasmic Reticulum.
Targeting of Proteins for Translocation at the Endoplasmic Reticulum.
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靶向蛋白质在内质网的易位。
DOI：
10.3390/ijms23073773
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发表时间：
2022-03-29
影响因子：
5.6
通讯作者：
Pool MR
中科院分区：
文献类型：
--
作者：
Pool MR
内质网是分泌途径的通道。在这里，用于分泌的蛋白质，以及存在于内膜系统和质膜中的可溶性和膜蛋白质，与将保留在细胞溶质中或靶向其他细胞器的蛋白质进行分类。这个过程需要准确识别特定的靶向信号和随后的递送机制，然后将它们靶向ER膜上存在的移位酶，这可以将它们移位到ER腔中或将它们插入脂质双层中。本次审查的重点是目前的理解，在这一过程中的第一步，即目标阶段。靶向通常由可切割的N-末端疏水信号序列或内膜锚序列介导;这些可以在核糖体上共捕获或在核糖体后识别，然后递送至ER移位酶。靶向序列的位置和特征决定了将使用几种重叠靶向途径底物中的哪一种。靶向机制或靶向信号的突变可能与疾病有关。
The endoplasmic reticulum represents the gateway to the secretory pathway. Here, proteins destined for secretion, as well as soluble and membrane proteins that reside in the endomembrane system and plasma membrane, are triaged from proteins that will remain in the cytosol or be targeted to other cellular organelles. This process requires the faithful recognition of specific targeting signals and subsequent delivery mechanisms to then target them to the translocases present at the ER membrane, which can either translocate them into the ER lumen or insert them into the lipid bilayer. This review focuses on the current understanding of the first step in this process representing the targeting phase. Targeting is typically mediated by cleavable N-terminal hydrophobic signal sequences or internal membrane anchor sequences; these can either be captured co-translationally at the ribosome or recognised post-translationally and then delivered to the ER translocases. Location and features of the targeting sequence dictate which of several overlapping targeting pathway substrates will be used. Mutations in the targeting machinery or targeting signals can be linked to diseases.
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DOI：
10.1126/science.1165971
发表时间：
2009-01-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bradshaw N;Neher SB;Booth DS;Walter P
通讯作者：
Walter P
影响因子：
8.8
作者：
Chio, Un Seng;Chung, SangYoon;Shan, Shu-ou
通讯作者：
Shan, Shu-ou
影响因子：
16.6
作者：
Hainzl, Tobias;Sauer-Eriksson, A. Elisabeth
通讯作者：
Sauer-Eriksson, A. Elisabeth
DOI：
10.1083/jcb.109.6.2653
发表时间：
1989-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Deshaies RJ;Schekman R
通讯作者：
Schekman R
DOI：
10.1073/pnas.1006036107
发表时间：
2010-07-06
影响因子：
11.1
作者：
Chartron, Justin W.;Suloway, Christian J. M.;Clemons, William M., Jr.
通讯作者：
Clemons, William M., Jr.