Tobacco-specific nitrosamines in new tobacco products
Tobacco-specific nitrosamines in new tobacco products
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DOI：
10.1080/14622200500490151
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发表时间：
2006-04-01
影响因子：
4.7
通讯作者：
Hecht, Stephen S.
中科院分区：
文献类型：
--
作者：
Stepanov, Irina;Jensen, Joni;Hecht, Stephen S.
市场上出现了新的烟草产品，旨在吸引关心烟草对健康影响的消费者。对这些产品进行客观评价的第一步需要获得关于其潜在毒性成分的数据。烟草特有的亚硝胺（TSNAs）是烟草制品中一类重要的致癌物质，但几乎没有关于这些产品中亚硝胺含量的数据。在本研究中，我们分析了几种新产品-Ariva，Stonewall，Exalt，Revel，Smokey Mountain和Quest-的TSNA，并将其TSNA水平与尼古丁替代产品和传统无烟烟草和卷烟品牌进行了比较。在Smokey Mountain中没有检测到TSNA，这是一种无烟草鼻烟产品。在含烟草的新产品中，Ariva和Stonewall的含量最低（0.26-0.28微克/克产品湿重）。新产品中含量最高的是Exalt（3.3微克/克烟草），而Revel和Quest的含量居中。在尼古丁替代产品中只发现了痕量，传统品牌的水平与文献报道的水平一致。这些结果显示，新烟草产品中的TSNA水平从相对较低到与某些传统品牌中的水平相当。
New tobacco products, designed to attract consumers who are concerned about the health effects of tobacco, have been appearing on the market. Objective evaluation of these products requires, as a first step, data on their potentially toxic constituents. Tobacco-specific nitrosamines (TSNAs) are an important class of carcinogens in tobacco products, but virtually no data were available on their levels in these products. In the present study, we analyzed several new products-Ariva, Stonewall, Exalt, Revel, Smokey Mountain, and Quest-for TSNAs and compared their TSNA levels with those in nicotine replacement products and conventional smokeless tobacco and cigarette brands. TSNAs were not detected in Smokey Mountain, which is a tobacco-free snuff product. The lowest levels among the new products containing tobacco were in Ariva and Stonewall (0.26-0.28 mu g/g wet weight of product). The highest levels in the new products were found in Exalt (3.3 mu g/g tobacco), whereas Revel and Quest had intermediate amounts. Only trace amounts were found in nicotine replacement products, and conventional brands had levels consistent with those reported in the literature. These results demonstrate that TSNA levels in new tobacco products range from relatively low to comparable with those found in some conventional brands.