Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses.
Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses.
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DOI：
10.1016/j.cell.2015.08.006
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发表时间：
2015-08-27
期刊：
影响因子：
64.5
通讯作者：
Misteli T
中科院分区：
文献类型：
--
作者：
Burgess RC;Misteli T
通常认为存在单一的典型DNA损伤反应（DDR），其保护细胞免受各种类型的双链断裂，并且其激活通过DDR机制识别DNA损伤而发生。最近的研究表明，这两种假设可能都过于简单化了。在这里，我们讨论了DDR的几种变化，其中该途径被不同的细胞事件激活或产生不同的信号转导结果。多个非规范DDR的存在提供了对DNA损伤如何被感测的见解，并表明DDR的高度模块化组织。
It is commonly assumed that there is a single canonical DNA damage response (DDR) that protects cells from various types of double-strand breaks and that its activation occurs via recognition of DNA damage by the DDR machinery. Recent work suggests that both assumptions may be oversimplifications. Here, we discuss several variations of the DDR in which the pathway is activated by diverse cellular events or generates distinct signaling outcomes. The existence of multiple non-canonical DDRs provides insights into how DNA damage is sensed and suggests a highly modular organization of the DDR.