Increased acidic fibroblast growth factor concentrations in the serum and cerebrospinal fluid of patients with Alzheimer's disease
Increased acidic fibroblast growth factor concentrations in the serum and cerebrospinal fluid of patients with Alzheimer's disease
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DOI：
10.1016/j.jocn.2009.05.037
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发表时间：
2010-03-01
影响因子：
2
通讯作者：
Naji, Mohammad
中科院分区：
文献类型：
--
作者：
Mashayekhi, Farhad;Hadavi, Mahvash;Naji, Mohammad
酸性成纤维细胞生长因子，又称成纤维细胞生长因子-1，在体外影响多种细胞的增殖和分化，最初是从神经组织中分离出来的。它从第三脑室的室管膜细胞释放到脑脊液(CSF)中。成纤维细胞生长因子-1促进神经元存活。阿尔茨海默病患者脑内反应性星形胶质细胞表达成纤维细胞生长因子-1。通过比较AD患者和正常对照组的脑脊液蛋白质组，有可能确定在AD中起作用的蛋白质。由于脑脊液与脑细胞外间隙接触，脑生化的改变可能会反映在脑脊液中。本研究的目的是测定AD患者血清和脑脊液中成纤维细胞生长因子-1的浓度。本研究采用脑脊液标本，分别来自AD患者(n=32)和非AD患者(n=32)。AD患者的脑脊液和血清中的FGF-1水平明显高于非AD患者。结论：成纤维细胞生长因子-1是人血清和脑脊液中的恒定成分，可能参与了AD的病理生理过程。(C)2009爱思唯尔有限公司。保留所有权利。
Acidic fibroblast growth factor (aFGF), also called FGF-1, which influences the proliferation and differentiation Of Various cell types in vitro, was originally isolated from neural tissue. It is released from the ependymal cells of the cerebral third ventricle into the cerebrospinal fluid (CSF). FGF-1 promotes the survival of neurons. Reactive astrocytes express FGF-1 in the brain of patients with Alzheimer's disease (AD). By comparing the CSF proteome of patients with AD and normal controls it might be possible to identify proteins that have a role in AD. Because CSF is in contact with the extracellular space of the brain, modifications in the brain biochemistry could be reflected in the CSF. The aim of this study was to determine concentrations of serum and CSF FGF-1 in patients with AD. This study consisted of 64 CSF samples, from patients with AD (n = 32) and those without (normal controls) (n = 32). The level of CSF and serum FGF-1 in patients with AD was higher than in patients without AD. We conclude that FGF-1 is a constant component of human serum and CSF and that FGF-1 may be involved in the pathophysiology of AD. (C) 2009 Elsevier Ltd. All rights reserved.