Maternal and umbilical cord androgen concentrations do not predict digit ratio (2D:4D) in girls: A prospective cohort study
Maternal and umbilical cord androgen concentrations do not predict digit ratio (2D:4D) in girls: A prospective cohort study
复制标题
DOI：
10.1016/j.psyneuen.2010.02.013
复制
发表时间：
2010-09-01
影响因子：
3.7
通讯作者：
Sloboda, D. M.
中科院分区：
文献类型：
--
作者：
Hickey, M.;Doherty, D. A.;Sloboda, D. M.
指长比（2D：4D）被广泛用作产前雄激素暴露的标志物。然而，目前还没有发表的前瞻性研究，产前雄激素暴露已被测量，并与成年生活中的手指比例。我们的目的是建立在怀孕的第二个和第三个三个月的产前雄激素暴露（通过母亲的循环雄激素浓度和脐带雄激素浓度测量）和青春期女孩的指比之间的前瞻性关系。雄激素浓度（睾酮，游离雄激素指数，雄烯二酮，DHEAS）和性激素结合球蛋白（SHBG）的测量储存的血浆样本从怀孕18周（n = 118）和34/36周（n = 114）和脐带血（n = 82）从西澳大利亚州妊娠（Raine）队列研究（www.rainestudy.org.au）。对来自该队列的244名14-16岁雌性后代进行了趾比测量。在妊娠18周的母体循环雄烯二酮水平和左手手指比率之间仅观察到一个临界统计学显著相关性。未观察到母体雄激素浓度或脐带雄激素浓度与青春期趾比之间存在其他统计学显著性关系。这些研究结果表明，在2D：40在女孩的变化是不成立的，在第二和第三孕期的睾酮浓度的结果。我们的结论是，产前雄激素暴露测量的母亲循环雄激素浓度在18和34/36周的妊娠或在出生时的脐带可能无法预测的数字比的女孩。(C)2010爱思唯尔有限公司版权所有。
Digit ratio (2D:4D) is widely used as a marker of prenatal androgen exposure. However, there are no published prospective studies where prenatal androgen exposure has been measured and correlated with digit ratio in adult life. We aimed to establish the prospective relationship between prenatal androgen exposure in the second and third trimesters of pregnancy (as measured by maternal circulating androgen concentrations and umbilical cord androgen concentrations) and digit ratio in adolescent girls. Androgen concentrations (testosterone, free androgen index, androstenedione, DHEAS) and sex hormone binding globulin (SHBG) were measured in stored plasma samples from pregnant mothers at 18 (n = 118) and 34/36 (n = 114) weeks of gestation and in cord blood (n = 82) from the Western Australian Pregnancy (Raine) Cohort Study (www.rainestudy.org.au). Digit ratio was measured in 244 female offspring from this cohort at age 14-16 years. Only one borderline statistically significant correlation between maternal circulating androstenedione levels at 18 weeks of gestation and left hand digit ratio was seen. No other statistically significant relationship between maternal androgen concentrations or umbilical cord androgen concentrations and digit ratio in adolescence were observed. These findings suggest that variation in 2D:40 in girls is not established as a result of testosterone concentrations in the second and third trimesters. We conclude that prenatal androgen exposure as measured by maternal circulating androgen concentrations at 18 and 34/36 weeks of gestation or in the umbilical cord at birth may not predict digit ratio in girls. (C) 2010 Elsevier Ltd. All rights reserved.