Association between the Lymphotoxin-α A252g Gene Polymorphism and the Risk of Sepsis and Mortality: A Meta-Analysis
Association between the Lymphotoxin-α A252g Gene Polymorphism and the Risk of Sepsis and Mortality: A Meta-Analysis
复制标题
DOI：
10.1155/2020/7936434
复制
发表时间：
2020-08-20
影响因子：
--
通讯作者：
Zhou, Yutian
中科院分区：
文献类型：
--
作者：
Guo, Shujin;Zuo, Qiunan;Zhou, Yutian
背景资料。淋巴毒素-α(LTA)A252G基因多态性与脓毒症风险之间的关系已被广泛研究，但结果存在争议。本研究旨在探讨LTAA252G基因多态与脓毒症/感染性休克风险及脓毒症相关死亡的总体相关性。方法：研究方法。我们检索了PubMed和EMBASE数据库，以确定研究LTA A252G多态与脓毒症、感染性休克和死亡率之间的关联的研究。提取相关数据，用Revman 5.0和Stata 12软件进行统计分析。结果。共有32种出版物被纳入荟萃分析。结果显示，LTAA252G基因多态性与脓毒症风险(GG+GAvs.AA：OR=0.92，95%CI=0.79-1.07，p=0.27)或败血症休克风险(GG+GAvs.AA：OR=1.01，95%CI=0.84-1.22，p=0.91)无显著相关性。然而，在按种族分析的亚组中，在隐性模型中，LTAA252G多态显著降低了亚洲人群的脓毒症风险[GGvs.GA+AA：OR=0.82，95%CI=0.68-0.99，p=0.04]，但在高加索人群中没有。此外，在存活和未存活的脓毒症患者之间的比较表明，LTAA252G多态降低了死亡风险[GG+GA与AA：OR=0.57，95%CI=0.41-0.80，P
Background. The association between the lymphotoxin-alpha(LTA) A252G polymorphism and sepsis risk has been extensively studied, but the results have been controversial. This study is aimed at investigating the overall association between the LTAA252G polymorphism and the risk of sepsis/septic shock and sepsis-related mortality. Methods. We searched the PubMed and EMBASE databases to identify studies that investigated the association between the LTA A252G polymorphism and risks of sepsis, septic shock, and mortality. The relevant data were extracted, and statistical analyses were performed using the Revman 5.0 and STATA 12 software. Results. A total of 32 publications were included in the meta-analysis. The results demonstrated that the LTAA252G polymorphism showed no significant association with sepsis risk (GG+GAvs.AA:OR=0.92,95%CI=0.79-1.07,p=0.27) or with sepsis shock risk (GG+GAvs.AA:OR=1.01,95%CI=0.84-1.22,p=0.91). However, in the subgroup analyzed by ethnicity, theLTAA252G polymorphism significantly decreased sepsis risk in the Asian population for the recessive model [GGvs.GA+AA:OR=0.82,95%CI=0.68-0.99,p=0.04] but not in the Caucasian population. Moreover, comparisons between sepsis patients who survived and those who did not suggested that theLTAA252G polymorphism decreases the risk of mortality [GG+GA vs. AA:OR=0.57,95%CI=0.41-0.80,p