A model of fulminant hepatic failure in the rabbit.
A model of fulminant hepatic failure in the rabbit.
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DOI：
10.5555/uri:pii:001650857890241x
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发表时间：
1978
期刊：
影响因子：
29.4
通讯作者：
B. Blitzer;J. Waggoner;E. Jones;H. Gralnick;D. Towne;J. Butler;V. Weise;I. Kopin;I. Walters;P. Teychenné;D. Goodman;P. Berk
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文献类型：
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作者：
B. Blitzer;J. Waggoner;E. Jones;H. Gralnick;D. Towne;J. Butler;V. Weise;I. Kopin;I. Walters;P. Teychenné;D. Goodman;P. Berk
通过给基因一致的家兔静脉注射选择性肝毒素盐酸半乳糖胺（4.25毫摩尔/千克），建立了高度可重复的暴发性肝衰竭模型。绝大多数家兔在注射后21 ~ 44小时死亡，平均昏迷时间为2.6小时。血清生化检查和肝脏组织学检查显示大量肝损伤。血浆氨和氨基酸浓度、凝血参数和脑电图的变化与人类暴发性肝衰竭相似。该模型为未来研究暴发性肝衰竭的发病机制和治疗提供了前景。
A highly reproducible model of fulminant hepatic failure was developed by administering intravenously the selective hepatotoxin galactosamine hydrochloride (4.25 mmoles per kg) to genetically uniform rabbits. The great majority of rabbits died between 21 and 44 hr after injection following a period of coma which lasted 2.6 hr on average. Serum biochemical tests and liver histology reflected massive hepatic injury. Changes in plasma ammonia and amino acid concentrations, in coagulation parameters, and in the electroencephalogram were similar to those found in human fulminant hepatic failure. This model appears promising for future studies of the pathogenesis and treatment of fulminant hepatic failure.