Dynamic Modeling and Analysis of the CrossTalk between Insulin/AKT and MAPK/ERK Signaling Pathways
Dynamic Modeling and Analysis of the CrossTalk between Insulin/AKT and MAPK/ERK Signaling Pathways
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DOI：
10.1371/journal.pone.0149684
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发表时间：
2016-03-01
期刊：
影响因子：
3.7
通讯作者：
Arkun, Yaman
中科院分区：
文献类型：
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作者：
Arkun, Yaman
反馈回路在信号转导网络复杂相互作用的调控中起着关键作用。通过在系统水平上研究信号通路中存在的生物分子之间的相互作用网络，有可能了解生物功能是如何被调节的，以及疾病是如何从它们的失调中产生的。本文确定了参与胰岛素- akt和MAPK/ERK信号通路串扰的关键反馈回路。我们开发了一个数学模型，可用于研究这两个重要信号通路之间相互作用的稳态和动态行为。建模分析和模拟案例研究确定了决定正常和疾病表型的关键相互作用参数和反馈回路。
Feedback loops play a key role in the regulation of the complex interactions in signal transduction networks. By studying the network of interactions among the biomolecules present in signaling pathways at the systems level, it is possible to understand how the biological functions are regulated and how the diseases emerge from their deregulations. This paper identifies the key feedback loops involved in the cross-talk among the insulin-AKT and MAPK/ERK signaling pathways. We developed a mathematical model that can be used to study the steady-state and dynamic behavior of the interactions among these two important signaling pathways. Modeling analysis and simulation case studies identify the key interaction parameters and the feedback loops that determine the normal and disease phenotypes.