The design of the prenatal determinants of schizophrenia study
The design of the prenatal determinants of schizophrenia study
复制标题
DOI：
10.1093/oxfordjournals.schbul.a033451
复制
发表时间：
2000-01-01
影响因子：
6.6
通讯作者：
Wyatt, RJ
中科院分区：
文献类型：
--
作者：
Susser, ES;Schaefer, CA;Wyatt, RJ
本文介绍了精神分裂症（PDS）研究的产前决定因素;三个配套文件报告的第一个结果。PDS研究的目的是研究1959-1967年出生队列中精神分裂症的早期前因，该队列有丰富的存档产前资料，包括母亲血清。利用该队列出生的健康计划登记处，我们确定并诊断了该队列中71例精神分裂症和谱系障碍。我们在此描述了可用的产前数据，病例诊断的过程中，用于分析产前决定因素的精神分裂症在这个队列的策略。所提供的数据与潜在偏倚的主要来源有关，对于理解这一独特数据集的优势和局限性非常重要。
This paper describes the Prenatal Determinants of Schizophrenia (PDS) Study; three companion papers report the first results. The PDS Study was designed to study early antecedents of schizophrenia in a birth cohort of 1959-1967 for whom a wealth of archived prenatal data-including maternal sera-was available, Making use of the registries of a health plan into which the cohort was born, we ascertained and then diagnosed 71 cases of schizophrenia and spectrum disorders in the cohort. We describe herein the available prenatal data, the process of case diagnosis, and the strategies used to analyze prenatal determinants of schizophrenia in this cohort. Data are presented that bear on the main sources of potential bias and are important to understanding the strengths and limitations of this unique data set.