Application of microfluidic devices in studies of thrombosis and hemostasis.
Application of microfluidic devices in studies of thrombosis and hemostasis.
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DOI：
10.1080/09537104.2017.1319047
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发表时间：
2017-07
期刊：
影响因子：
3.3
通讯作者：
Neelamegham S
中科院分区：
文献类型：
--
作者：
Zhang C;Neelamegham S
由于血栓发作期间流体流动的重要性，在具有明确流体剪切环境的设备中研究凝血和出血过程是非常合适的。用于施加这些定义的剪切应力的两种常见装置包括锥板粘度计和平行板流室。虽然这些工具有许多显著的特点，但它们需要大量的血液或其他蛋白质成分。在过去的二十年里，随着微流体领域的发展，这种流动装置的小型化已经成为可能。这种小型化不仅可以节省宝贵的样品，还可以增加流体剪切装置的吞吐量，从而使组合实验的设计成为可能，并使该技术更容易被更大的科学界所接受。除了传统血流仪中常见的简单血流外，还可以生成更复杂的几何形状，模拟狭窄的动脉和人体微血管系统。微流体细胞底物的组成也可以根据不同的基础科学研究和临床研究而变化，目的是分析个体患者的凝血病或对抗凝治疗的反应。本文综述了微流控装置的研究现状及其在血栓和止血领域的应用。
Due to the importance of fluid flow during thrombotic episodes, it is quite appropriate to study clotting and bleeding processes in devices that have well-defined fluid shear environments. Two common devices for applying these defined shear stresses include the cone-and-plate viscometer and parallel-plate flow chamber. While such tools have many salient features, they require large amounts of blood or other protein components. With growth in the area of microfluidics over the last two decades, it has become feasible to miniaturize such flow devices. Such miniaturization not only enables saving of precious samples but also increases the throughput of fluid shear devices, thus, enabling the design of combinatorial experiments and making the technique more accessible to the larger scientific community. In addition to simple flows that are common in traditional flow apparatus, more complex geometries that mimic stenosed arteries and the human microvasculature can also be generated. The composition of the microfluidics cell substrate can also be varied for diverse basic science investigations, and clinical investigations that aim to assay either individual patient coagulopathy or response to anti-coagulation treatment. This review summarizes the current state of the art for such microfluidic devices and their applications in the field of thrombosis and hemostasis.
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