Differential endocannabinoid regulation of extinction in appetitive and aversive Barnes maze tasks
Differential endocannabinoid regulation of extinction in appetitive and aversive Barnes maze tasks
复制标题
DOI：
10.1101/lm.1113008
复制
发表时间：
2008-11-01
影响因子：
2
通讯作者：
Lichtman, Aron H.
中科院分区：
文献类型：
--
作者：
Harloe, John P.;Thorpe, Andrew J.;Lichtman, Aron H.
CB（1）受体受损的动物在消除厌恶条件反射任务中的学习行为方面表现出严重的缺陷，但在食欲操作性任务中表现出正常的消除学习。然而，很难辨别内源性大麻素系统对灭绝的差异参与是否来自于享乐或与不同任务相关的所需反应。在这里，我们报告CB（1）受体拮抗剂利莫那班破坏了在一个厌恶，但不是在一个食欲，巴恩斯迷宫条件反射任务的消退学习。因此，这些结果提供了令人信服的支持的假设，即内源性大麻素系统中起着必要的作用，在灭绝的厌恶动机的行为，但消耗的食欲动机的行为。
CB(1) receptor-compromised animals show profound deficits in extinguishing learned behavior from aversive conditioning tasks, but display normal extinction learning in appetitive operant tasks. However, it is difficult to discern whether the differential involvement of the endogenous cannabinoid system on extinction results from the hedonics or the required responses associated with the disparate tasks. Here, we report that the CB(1) receptor antagonist rimonabant disrupts extinction learning in an aversive, but not in an appetitive, Barnes maze conditioning task. Accordingly, these results provide compelling support for the hypothesis that the endogenous cannabinoid system plays a necessary role in the extinction of aversively motivated behaviors but is expendable for appetitively motivated behaviors.