Structure-binding relation of philanthotoxins from nicotinic acetylcholine receptor binding assay.
Structure-binding relation of philanthotoxins from nicotinic acetylcholine receptor binding assay.
复制标题
烟碱乙酰胆碱受体结合测定中花椒毒素的结构结合关系。
DOI：
10.1016/s0968-0896(97)00137-5
复制
发表时间：
1997
影响因子：
3.5
通讯作者：
Eldefrawi,M
中科院分区：
文献类型：
--
作者：
Nakanishi,K;Huang,X;Jiang,H;Liu,Y;Fang,K;Huang,D;Choi,SK;Katz,E;Eldefrawi,M
Philanthotoxins是烟碱乙酰胆碱受体和各种谷氨酸受体的非竞争性抑制剂。类似物进行光亲和标记，氟原子的配体/受体相互作用的固态NMR研究，和大的头部基团，如卟啉和平面庞大的芳香环（BIG类似物），用于澄清模式的进入和取向的类似物在受体已合成，测定对烟碱乙酰胆碱受体，并简要评论的测定结果。
Philanthotoxins are noncompetitive inhibitors of the nicotinic acetylcholine receptor and the various glutamate receptors. Analogues carrying photoaffinity labels, fluorine atoms for solid-state NMR studies of ligand/receptor interaction, and large head groups such as porphyrins and planar bulky aromatic rings (BIG analogues) for clarifying mode of entry and orientation of analogues in receptors have been synthesized, assayed against the nicotinic acetylcholine receptor, and brief comments are given for the assay results.